Obesity and Pancreatic Cancer: Insight into Mechanisms.
Obesity and Pancreatic Cancer: Insight into Mechanisms.
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DOI：
10.3390/cancers13205067
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发表时间：
2021-10-10
期刊：
影响因子：
5.2
通讯作者：
Rozengurt E
中科院分区：
文献类型：
--
作者：
Eibl G;Rozengurt E
肥胖被认为是一种慢性进行性疾病，是许多人类疾病的危险因素。肥胖人数居高不下且不断增加，可能是美国胰腺癌病例预期增加的基础。关于肥胖与胰腺癌之间的关系，有几种途径进行了讨论。脂肪组织和脂肪组织释放因子可能因此发挥重要作用。这篇综述讨论了肥胖症中可能加速胰腺癌发展的部分机制。在过去的几十年里，成年人和儿童的肥胖率急剧上升。肥胖已被宣布为慢性进行性疾病，是许多代谢性、炎症性和肿瘤性疾病的危险因素。有明确的流行病学和临床前证据表明，肥胖是胰腺癌的危险因素。在将肥胖与胰腺癌联系起来的各种潜在机制中，脂肪组织和肥胖相关的脂肪组织炎症起着核心作用。目前的综述讨论了最近引起人们兴趣的选定主题和机制，这些主题和机制可能是肥胖促进胰腺癌作用的基础。这些主题包括肥胖对KRAS活性的影响、内脏脂肪组织、胰腺内脂肪、脂肪组织炎症和脂肪因子在胰腺癌发展中的作用。讨论了Lipocalin-2、成纤维细胞生长因子21和Wnt5a的研究现状。此外，还对肥胖相关的胰岛素抵抗与高胰岛素血症和肥胖引起的肠道代谢紊乱与代谢性内毒素血症的关系进行了综述。鉴于脂肪组织在肥胖促进的胰腺癌发展中所起的核心作用，预防和拦截策略应该旨在减轻肥胖相关的脂肪组织炎症和/或靶向特定的分子，这些分子机械地将脂肪组织与肥胖患者的胰腺癌联系起来。
Obesity is recognized as a chronic progressive disease and risk factor for many human diseases. The high and increasing number of obese people may underlie the expected increase in pancreatic cancer cases in the United States. There are several pathways discussed that link obesity with pancreatic cancer. Adipose tissue and adipose tissue-released factors may thereby play an important role. This review discusses selected mechanisms that may accelerate pancreatic cancer development in obesity. The prevalence of obesity in adults and children has dramatically increased over the past decades. Obesity has been declared a chronic progressive disease and is a risk factor for a number of metabolic, inflammatory, and neoplastic diseases. There is clear epidemiologic and preclinical evidence that obesity is a risk factor for pancreatic cancer. Among various potential mechanisms linking obesity with pancreatic cancer, the adipose tissue and obesity-associated adipose tissue inflammation play a central role. The current review discusses selected topics and mechanisms that attracted recent interest and that may underlie the promoting effects of obesity in pancreatic cancer. These topics include the impact of obesity on KRAS activity, the role of visceral adipose tissue, intrapancreatic fat, adipose tissue inflammation, and adipokines on pancreatic cancer development. Current research on lipocalin-2, fibroblast growth factor 21, and Wnt5a is discussed. Furthermore, the significance of obesity-associated insulin resistance with hyperinsulinemia and obesity-induced gut dysbiosis with metabolic endotoxemia is reviewed. Given the central role that is occupied by the adipose tissue in obesity-promoted pancreatic cancer development, preventive and interceptive strategies should be aimed at attenuating obesity-associated adipose tissue inflammation and/or at targeting specific molecules that mechanistically link adipose tissue with pancreatic cancer in obese patients.
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影响因子：
7.7
作者：
Cani, Patrice D.;Amar, Jacques;Burcelin, Remy
通讯作者：
Burcelin, Remy
影响因子：
7.7
作者：
Andersen DK;Korc M;Petersen GM;Eibl G;Li D;Rickels MR;Chari ST;Abbruzzese JL
通讯作者：
Abbruzzese JL
影响因子：
2.9
作者：
Abbruzzese JL;Andersen DK;Borrebaeck CAK;Chari ST;Costello E;Cruz-Monserrate Z;Eibl G;Engleman EG;Fisher WE;Habtezion A;Kim SK;Korc M;Logsdon C;Lyssiotis CA;Pandol SJ;Rustgi A;Wolfe BM;Zheng L;Powers AC
通讯作者：
Powers AC
DOI：
10.1038/s41575-020-0324-6
发表时间：
2020-08
期刊：
Nature reviews. Gastroenterology & hepatology
影响因子：
--
作者：
Eibl G
通讯作者：
Eibl G
影响因子：
29.4
作者：
Bouter, Kristien E.;van Raalte, Daniel H.;Nieuwdorp, Max
通讯作者：
Nieuwdorp, Max