Roles of Noncoding RNA in Reproduction.
Roles of Noncoding RNA in Reproduction.
复制标题
非编码 RNA 在生殖中的作用
DOI：
10.3389/fgene.2021.777510
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发表时间：
2021
影响因子：
3.7
通讯作者：
Liang M
中科院分区：
文献类型：
--
作者：
He C;Wang K;Gao Y;Wang C;Li L;Liao Y;Hu K;Liang M
世界卫生组织预测，不孕不育将成为仅次于癌症和心血管疾病的第三大健康威胁，并将成为医学研究的热门话题。研究表明，表观遗传变化是配子发生和相关生殖疾病的重要组成部分。非编码RNA(NcRNA)的表观遗传调控是生物医学领域的研究热点，包括长非编码RNA(LncRNA)、微小RNA(MiRNA)和PIWI相互作用RNA(PiRNA)。作为细胞内基因调控网络的重要成员，它们影响着细胞的各种生命活动。通过分子引导，lncRNA在体内发挥着分子诱饵、分子信号和分子支架的作用。MiRNAs是基因表达的关键调控因子，主要控制转录后靶基因的稳定性或翻译。在动物生殖细胞中，PiRNA主要通过沉默基因组转座元件和mRNAs的转录后调控发挥作用。目前的研究表明，这些ncRNAs在生殖系统中也发挥着重要的作用，并参与调节精子发生和卵泡发育中的基本细胞事件。NcRNA的异常表达与睾丸生殖细胞肿瘤、多囊卵巢综合征等疾病密切相关。本文简要介绍了涉及ncRNAs的生殖过程和生殖疾病的研究进展。
The World Health Organization predicts that infertility will be the third major health threat after cancer and cardiovascular disease, and will become a hot topic in medical research. Studies have shown that epigenetic changes are an important component of gametogenesis and related reproductive diseases. Epigenetic regulation of noncoding RNA (ncRNA) is appropriate and is a research hotspot in the biomedical field; these include long noncoding RNA (lncRNA), microRNA (miRNA), and PIWI-interacting RNA (piRNA). As vital members of the intracellular gene regulatory network, they affect various life activities of cells. LncRNA functions as a molecular bait, molecular signal and molecular scaffold in the body through molecular guidance. miRNAs are critical regulators of gene expression; they mainly control the stability or translation of their target mRNA after transcription. piRNA functions mainly through silencing genomic transposable elements and the post-transcriptional regulation of mRNAs in animal germ cells. Current studies have shown that these ncRNAs also play significant roles in the reproductive system and are involved in the regulation of essential cellular events in spermatogenesis and follicular development. The abnormal expression of ncRNA is closely linked to testicular germ cell tumors, poly cystic ovary syndrome and other diseases. This paper briefly presents the research on the reproductive process and reproductive diseases involving ncRNAs.
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影响因子：
16.1
作者：
Beavers, Kelsey R.;Nelson, Christopher E.;Duvall, Craig L.
通讯作者：
Duvall, Craig L.
DOI：
10.1111/asj.12200
发表时间：
2014-06
期刊：
Animal science journal = Nihon chikusan Gakkaiho
影响因子：
--
作者：
Emori C;Sugiura K
通讯作者：
Sugiura K
影响因子：
4.5
作者：
Anguera MC;Ma W;Clift D;Namekawa S;Kelleher RJ 3rd;Lee JT
通讯作者：
Lee JT
影响因子：
5.2
作者：
Butler, Alexandra E.;Ramachandran, Vimal;Atkin, Stephen L.
通讯作者：
Atkin, Stephen L.
影响因子：
2.9
作者：
Dada, R;Gupta, NP;Kucheria, K
通讯作者：
Kucheria, K