Role of oocyte-derived paracrine factors in follicular development.

Role of oocyte-derived paracrine factors in follicular development.
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DOI:
10.1111/asj.12200
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发表时间:
2014-06
期刊:
Animal science journal = Nihon chikusan Gakkaiho
影响因子:
--
通讯作者:
Sugiura K
Sugiura K
中科院分区:
其他
文献类型:
--
作者:
Emori C;Sugiura K

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哺乳动物卵母细胞分泌转化生长因子β (TGF-β)超家族蛋白,如生长分化因子9 (GDF9)、骨形态发生蛋白6 (BMP6)和BMP15,以及成纤维细胞生长因子(FGFs)。这些卵母细胞衍生的旁分泌因子(ODPFs)在调节体细胞颗粒细胞的分化和功能以及卵泡的发育中起着重要作用。除了单个ODPF的重要性外,新出现的证据表明,ODPF信号与其他卵泡内信号(如雌激素)的相互作用对卵泡形成至关重要。在这篇综述中,我们将讨论目前对ODPFs在卵泡发育中的作用的理解,重点是它们在调节颗粒细胞分化和功能方面与雌激素信号的相互作用。
Mammalian oocytes secrete transforming growth factor β (TGF-β) superfamily proteins, such as growth differentiation factor 9 (GDF9), bone morphogenetic protein 6 (BMP6) and BMP15, and fibroblast growth factors (FGFs). These oocyte-derived paracrine factors (ODPFs) play essential roles in regulating the differentiation and function of somatic granulosa cells as well as the development of ovarian follicles. In addition to the importance of individual ODPFs, emerging evidence suggests that the interaction of ODPF signals with other intra-follicular signals, such as estrogen, is critical for folliculogenesis. In this review, we will discuss the current understanding of the role of ODPFs in follicular development with an emphasis on their interaction with estrogen signaling in regulation of the differentiation and function of granulosa cells.
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