Selective targeting of biting females to control mosquito-borne infectious diseases.

Selective targeting of biting females to control mosquito-borne infectious diseases.
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DOI:
10.1016/j.pt.2022.05.012
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发表时间:
2022-09
影响因子:
9.6
通讯作者:
Tu, Zhijian
Tu, Zhijian
中科院分区:
医学1区
文献类型:
--
作者:
Kojin, Bianca B.;Compton, Austin;Adelman, Zach N.;Tu, Zhijian

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蚊子是许多传染病的传播媒介。只有雌性以血液为食,为其胚胎提供养分,并以此将病原体传播给相关的脊椎动物宿主。因此,性别是遗传控制程序背景下的一个重要表型,既可以在饲养设施中进行性别分离以避免释放咬人的雌性,也可以扭曲不咬人的雄性的性别比例。本文综述了蚊子性别决定和性染色体基础知识的最新进展,并讨论了实现性别分离和性别比例扭曲的新方法,以帮助控制蚊媒传染病。最后,我们提出了未来研究的几个关键领域。
Mosquitoes are vectors for a number of infectious diseases. Only females feed on blood to provision for their embryos and in doing so transmit pathogens to the associated vertebrate hosts. Therefore, sex is an important phenotype in the context of genetic control programs, both for sex separation in the rearing facilities to avoid releasing the biting females and for ways to distort the sex ratio towards the non-biting males. We review recent progress in the fundamental knowledge of sex determination and sex chromosomes in mosquitoes and discuss new methods to achieve sex separation and sex ratio distortion to help control mosquito-borne infectious diseases. We conclude by suggesting a few critical areas for future research.
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