Effects of hippocampal interictal discharge timing, duration, and spatial extent on list learning.
Effects of hippocampal interictal discharge timing, duration, and spatial extent on list learning.
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DOI：
10.1016/j.yebeh.2021.108209
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发表时间：
2021-10
影响因子：
2.6
通讯作者：
Devinsky, Orrin
中科院分区：
文献类型：
--
作者：
Leeman-Markowski, Beth;Hardstone, Richard;Lohnas, Lynn;Cowen, Benjamin;Davachi, Lila;Doyle, Werner;Dugan, Patricia;Friedman, Daniel;Liu, Anli;Melloni, Lucia;Selesnick, Ivan;Wang, Binhuan;Meador, Kimford;Devinsky, Orrin
发作间期癫痫样放电（IED）会损害记忆力。然而，简易爆炸装置对记忆最有害的特性是不确定的。我们研究了IED的时间和空间特征对列表学习的影响。受试者在颅内EEG记录期间完成记忆任务，包括海马深度和颞叶新皮质硬膜下电极。受试者观看了一系列的物体，并在一个分散注意力的任务后，从列表中回忆的对象。IED的存在，持续时间和传播到新皮层在编码的个人刺激的影响进行了评估。还确定了维持和回忆期间IED总数和持续时间对延迟回忆表现的影响。通过比较在正确回忆的项目之前的IED的可能性与没有口头反应的时期，进一步研究了在回忆过程中IED的影响。在6名受试者中，我们分析了28个海马和139个侧颞接触。回忆表现不佳，正确回答的中位数为17.2%（范围10.4-21.9%）。在编码，维护和回忆过程中的简易爆炸装置并没有显着影响任务的性能，并有简易爆炸装置的可能性之间没有显着差异，在正确的回忆与没有反应的时期。在编码、维持或回忆期间，放电持续时间没有显著影响。在编码过程中扩散到外侧颞叶皮层的IED不会对回忆产生不利影响。一项改进模型假设的事后分析表明，在维护期间，简易爆炸装置的数量产生了负面影响，但在其他方面证实了上述结果。我们的研究结果表明，海马IED列表学习没有重大影响，但研究的局限性，如基线海马功能障碍，应予以考虑。简易爆炸装置在维持期间的影响可能是今后研究的一个重点。
Interictal epileptiform discharges (IEDs) can impair memory. The properties of IEDs most detrimental to memory, however, are undefined. We studied the impact of temporal and spatial characteristics of IEDs on list learning. Subjects completed a memory task during intracranial EEG recordings including hippocampal depth and temporal neocortical subdural electrodes. Subjects viewed a series of objects, and after a distracting task, recalled the objects from the list. The impacts of IED presence, duration, and propagation to neocortex during encoding of individual stimuli were assessed. The effects of IED total number and duration during maintenance and recall periods on delayed recall performance were also determined. The influence of IEDs during recall was further investigated by comparing the likelihood of IEDs preceding correctly recalled items vs. periods of no verbal response. Across 6 subjects, we analyzed 28 hippocampal and 139 lateral temporal contacts. Recall performance was poor, with a median of 17.2% correct responses (range 10.4–21.9%). IEDs during encoding, maintenance, and recall did not significantly impact task performance, and there was no significant difference between the likelihood of IEDs during correct recall vs. periods of no response. No significant effects of discharge duration during encoding, maintenance, or recall were observed. IEDs with spread to lateral temporal cortex during encoding did not adversely impact recall. A post-hoc analysis refining model assumptions indicated a negative impact of IED count during the maintenance period, but otherwise confirmed the above results. Our findings suggest no major effect of hippocampal IEDs on list learning, but study limitations, such as baseline hippocampal dysfunction, should be considered. The impact of IEDs during the maintenance period may be a focus of future research.
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影响因子：
16.2
作者：
Tompary A;Davachi L
通讯作者：
Davachi L
影响因子：
5.6
作者：
Horak PC;Meisenhelter S;Song Y;Testorf ME;Kahana MJ;Viles WD;Bujarski KA;Connolly AC;Robbins AA;Sperling MR;Sharan AD;Worrell GA;Miller LR;Gross RE;Davis KA;Roberts DW;Lega B;Sheth SA;Zaghloul KA;Stein JM;Das SR;Rizzuto DS;Jobst BC
通讯作者：
Jobst BC
影响因子：
5.6
作者：
Fitzgerald, Zoe;Thayer, Zoe;Miller, Laurie A.
通讯作者：
Miller, Laurie A.
影响因子：
5.3
作者：
Reed, Chrystal M.;Mosher, Clayton P.;Rutishauser, Ueli
通讯作者：
Rutishauser, Ueli
影响因子：
56.9
作者：
Polyn, SM;Natu, VS;Norman, KA
通讯作者：
Norman, KA