Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex.
Consolidation Promotes the Emergence of Representational Overlap in the Hippocampus and Medial Prefrontal Cortex.
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DOI：
10.1016/j.neuron.2017.09.005
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发表时间：
2017-09-27
期刊：
影响因子：
16.2
通讯作者：
Davachi L
中科院分区：
文献类型：
--
作者：
Tompary A;Davachi L
结构化知识被认为部分是通过重叠经验中的规律性的提取和表示而形成的。然而，人们对巩固过程如何改变新颖的情景记忆以反映这种规律性知之甚少。在一项为期多天的功能磁共振成像研究中，参与者编码了与其他试验共享特征的试验独特关联。使用多变量模式分析来测量这些关联的即时检索和一周检索期间重叠和非重叠记忆的神经相似性。我们发现海马体和内侧前额叶皮层的神经模式代表了记忆之间的特征重叠，但只是在一周之后。此外，一周后，记忆在检索过程中独特的情景恢复的强度与其重叠的表示呈负相关，这表明相关记忆的整合和情景细节的恢复之间存在权衡。这些发现表明，神经表征中与巩固相关的变化支持将离散事件逐渐组织成结构化知识。
Structured knowledge is thought to form, in part, through the extraction and representation of regularities across overlapping experiences. However, little is known about how consolidation processes may transform novel episodic memories to reflect such regularities. In a multi-day fMRI study, participants encoded trial-unique associations that shared features with other trials. Multi-variate pattern analyses were used to measure neural similarity across overlapping and non-overlapping memories during immediate and one-week retrieval of these associations. We found that neural patterns in the hippocampus and medial prefrontal cortex represented the featural overlap across memories, but only after a week. Furthermore, after a week, the strength of a memory's unique episodic reinstatement during retrieval was inversely related to its representation of overlap, suggesting a trade-off between the integration of related memories and recovery of episodic details. These findings suggest that consolidation-related changes in neural representations support the gradual organization of discrete episodes into structured knowledge.
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影响因子：
3.7
作者：
Harand C;Bertran F;La Joie R;Landeau B;Mézenge F;Desgranges B;Peigneux P;Eustache F;Rauchs G
通讯作者：
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DOI：
10.1016/j.cub.2009.04.028
发表时间：
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期刊：
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