Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia.
Endocannabinoid System Unlocks the Puzzle of Autism Treatment via Microglia.
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内源性大麻素系统解开了小胶质细胞治疗自闭症的谜团
DOI：
10.3389/fpsyt.2021.734837
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发表时间：
2021
影响因子：
4.7
通讯作者：
Pei L
中科院分区：
文献类型：
--
作者：
Su T;Yan Y;Li Q;Ye J;Pei L
自闭症谱系障碍（ASD）是一种严重的神经发育障碍，其特征是儿童早期社交互动和沟通障碍、行为或兴趣模式受限和重复。目前ASD尚无有效的治疗方法，其发病机制尚不清楚。遗传和表观遗传因素被认为是ASD的主要原因。已知内源性大麻素及其受体广泛分布于中枢神经系统中，并向更生理性的神经发育提供积极且不可逆的变化。近年来，内源性大麻素系统（endocannabinoid system，ECS）被发现参与社会奖赏行为的调节，引起了神经科学家和神经学家的广泛关注。动物模型和临床研究都表明，ECS是治疗自闭症的潜在靶点，但其机制尚不清楚。在大脑中，小胶质细胞表达完整的ECS信号系统。研究还表明，调节ECS信号可以调节小胶质细胞的功能。通过全面回顾以往的研究，并结合我们最近的工作，本文综述了靶向ECS对小胶质细胞的影响，以及这如何有助于维持中枢神经系统的积极性，从而改善自闭症的症状。这将为揭示自闭症的发病机制和开发新的治疗策略提供新的见解。
Autism spectrum disorder (ASD) is a serious neurodevelopmental disorder and characterized by early childhood-onset impairments in social interaction and communication, restricted and repetitive patterns of behavior or interests. So far there is no effective treatment for ASD, and the pathogenesis of ASD remains unclear. Genetic and epigenetic factors have been considered to be the main cause of ASD. It is known that endocannabinoid and its receptors are widely distributed in the central nervous system, and provide a positive and irreversible change toward a more physiological neurodevelopment. Recently, the endocannabinoid system (ECS) has been found to participate in the regulation of social reward behavior, which has attracted considerable attention from neuroscientists and neurologists. Both animal models and clinical studies have shown that the ECS is a potential target for the treatment of autism, but the mechanism is still unknown. In the brain, microglia express a complete ECS signaling system. Studies also have shown that modulating ECS signaling can regulate the functions of microglia. By comprehensively reviewing previous studies and combining with our recent work, this review addresses the effects of targeting ECS on microglia, and how this can contribute to maintain the positivity of the central nervous system, and thus improve the symptoms of autism. This will provide insights for revealing the mechanism and developing new treatment strategies for autism.
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DOI：
10.1002/aur.1529
发表时间：
2016-03
期刊：
Autism research : official journal of the International Society for Autism Research
影响因子：
--
作者：
Jaramillo TC;Speed HE;Xuan Z;Reimers JM;Liu S;Powell CM
通讯作者：
Powell CM
DOI：
10.1016/j.bbi.2016.07.152
发表时间：
2016-11
期刊：
Brain, behavior, and immunity
影响因子：
--
作者：
Doenni VM;Gray JM;Song CM;Patel S;Hill MN;Pittman QJ
通讯作者：
Pittman QJ
影响因子：
3.3
作者：
Fusar-Poli L;Cavone V;Tinacci S;Concas I;Petralia A;Signorelli MS;Díaz-Caneja CM;Aguglia E
通讯作者：
Aguglia E
影响因子：
6.2
作者：
Aran, Adi;Eylon, Maya;Tam, Joseph
通讯作者：
Tam, Joseph
影响因子：
5.6
作者：
Brigida AL;Schultz S;Cascone M;Antonucci N;Siniscalco D
通讯作者：
Siniscalco D