Functional changes in neural mechanisms underlying post-traumatic stress disorder in World Trade Center responders.
Functional changes in neural mechanisms underlying post-traumatic stress disorder in World Trade Center responders.
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DOI：
10.1038/s41398-023-02526-y
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发表时间：
2023-07-11
影响因子：
6.8
通讯作者：
Horton, Megan K.
中科院分区：
文献类型：
--
作者：
Invernizzi, Azzurra;Rechtman, Elza;Curtin, Paul;Papazaharias, Demetrios M.;Jalees, Maryam;Pellecchia, Alison C.;Santiago-Michels, Stephanie;Bromet, Evelyn J.;Lucchini, Roberto G.;Luft, Benjamin J.;Clouston, Sean A.;Tang, Cheuk Y.;Horton, Megan K.
世界贸易中心（WTC）的救援人员在救援和恢复工作中暴露于创伤和环境压力源，慢性WTC相关的创伤后应激障碍（WTC-PTSD）的患病率很高。我们研究了WTC-PTSD的神经机制，通过应用特征向量中心性（EC）度量和数据驱动的方法在静息态功能磁共振（fMRI）。我们确定了EC差异与WTC暴露和行为症状的关系。我们发现，WTC-PTSD和非PTSD反应者在9个大脑区域的连接性显著不同，因为这些差异允许仅基于静息状态数据分析有效区分PTSD和非PTSD反应者。此外，我们发现，WTC暴露时间（现场月）缓和PTSD和EC值之间的关联在两个九个大脑区域;右前海马旁回和左杏仁核（p = 0.010; p = 0.005，分别调整多重比较）。在WTC-PTSD中，症状严重程度的维度测量与右前海马旁回和脑干的EC值呈正相关。功能神经影像学可以提供有效的工具，以确定诊断和创伤后应激障碍的维度指标的神经相关。
World Trade Center (WTC) responders exposed to traumatic and environmental stressors during rescue and recovery efforts have a high prevalence of chronic WTC-related post-traumatic stress disorder (WTC-PTSD). We investigated neural mechanisms underlying WTC-PTSD by applying eigenvector centrality (EC) metrics and data-driven methods on resting state functional magnetic resonance (fMRI). We identified how EC differences relate to WTC-exposure and behavioral symptoms. We found that connectivity differentiated significantly between WTC-PTSD and non-PTSD responders in nine brain regions, as these differences allowed an effective discrimination of PTSD and non-PTSD responders based solely on analysis of resting state data. Further, we found that WTC exposure duration (months on site) moderates the association between PTSD and EC values in two of the nine brain regions; the right anterior parahippocampal gyrus and the left amygdala (p = 0.010; p = 0.005, respectively, adjusted for multiple comparisons). Within WTC-PTSD, a dimensional measure of symptom severity was positively associated with EC values in the right anterior parahippocampal gyrus and brainstem. Functional neuroimaging can provide effective tools to identify neural correlates of diagnostic and dimensional indicators of PTSD.
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DOI：
10.1038/s41583-018-0039-7
发表时间：
2018-09
期刊：
Nature reviews. Neuroscience
影响因子：
--
作者：
Fenster RJ;Lebois LAM;Ressler KJ;Suh J
通讯作者：
Suh J
影响因子：
4.8
作者：
Demaria G;Invernizzi A;Ombelet D;Carvalho JC;Renken RJ;Cornelissen FW
通讯作者：
Cornelissen FW
近期发生创伤后应激障碍的患者在一次长期创伤暴露后皮质变薄
影响因子：
3.7
作者：
Liu Y;Li YJ;Luo EP;Lu HB;Yin H
通讯作者：
Yin H
影响因子：
7.7
作者：
Dasaro, Christopher R.;Holden, William L.;Todd, Andrew C.
通讯作者：
Todd, Andrew C.
影响因子：
3.3
作者：
Clouston, Sean A. P.;Guralnik, Jack M.;Luft, Benjamin J.
通讯作者：
Luft, Benjamin J.