Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic.
Multicentre service evaluation of presentation of newly diagnosed cancers and type 1 diabetes in children in the UK during the COVID-19 pandemic.
复制标题
在COVID-19大流行期间，英国儿童新诊断的癌症和1型糖尿病的表现的多中心服务评估。
DOI：
10.1136/bmjpo-2021-001078
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发表时间：
2021
影响因子：
2.6
通讯作者：
Walker D
中科院分区：
文献类型：
--
作者：
Williams G;McLean R;Liu JF;Ritzmann TA;Dandapani M;Shanmugavadivel D;Sachdev P;Brougham M;Mitchell RT;Conway NT;Law J;Cunnington A;Ogunnaike G;Brougham K;Bayman E;Walker D
COVID-19 大流行导致急诊科的就诊模式发生了变化。儿童健康专业人士担心，这可能会导致危及生命的疾病的延迟诊断，包括儿童癌症 (CC) 和 1 型糖尿病 (T1DM)。我们位于英国的多中心服务评估评估了这些病症的诊断间隔和疾病严重程度。我们收集了2020年1月1日至7月31日以及2019年同期期间三个主要治疗中心新诊断CC儿童和四个中心新诊断T1DM儿童的发病途径、时间和疾病严重程度。比较不同时间段的总诊断间隔（TDI）、患者间隔（PI）、系统间隔（SI）和疾病严重程度。对于 CC 和 T1DM，诊断途径和就诊时疾病的严重程度在所有时间段内都没有变化。封锁期间 CC 的诊断间隔与 2019 年相当（TDI 4.6、PI 1.1 和 SI 2.1 周），但 2020 年 1 月至 3 月 PI 有所增加（中位 2.7 周）。封锁期间 T1DM 的诊断间隔与 2019 年相似（TDI 16 天与 15 天，PI 14 天与 14 天），但 2020 年 1 月至 3 月 PI 有所增加（中位 21 天）。在各参与中心的大流行第一阶段，没有证据表明 CC 或 T1DM 的诊断延迟或疾病严重程度增加。这为患有这些改变生活状况的儿童和家庭提供了令人放心的数据。
The COVID-19 pandemic led to changes in patterns of presentation to emergency departments. Child health professionals were concerned that this could contribute to the delayed diagnosis of life-threatening conditions, including childhood cancer (CC) and type 1 diabetes (T1DM). Our multicentre, UK-based service evaluation assessed diagnostic intervals and disease severity for these conditions. We collected presentation route, timing and disease severity for children with newly diagnosed CC in three principal treatment centres and T1DM in four centres between 1 January and 31 July 2020 and the corresponding period in 2019. Total diagnostic interval (TDI), patient interval (PI), system interval (SI) and disease severity across different time periods were compared. For CCs and T1DM, the route to diagnosis and severity of illness at presentation were unchanged across all time periods. Diagnostic intervals for CCs during lockdown were comparable to that in 2019 (TDI 4.6, PI 1.1 and SI 2.1 weeks), except for an increased PI in January–March 2020 (median 2.7 weeks). Diagnostic intervals for T1DM during lockdown were similar to that in 2019 (TDI 16 vs 15 and PI 14 vs 14 days), except for an increased PI in January–March 2020 (median 21 days). There is no evidence of diagnostic delay or increased illness severity for CC or T1DM, during the first phase of the pandemic across the participating centres. This provides reassuring data for children and families with these life-changing conditions.
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影响因子：
6.2
作者：
Saab, Raya;Obeid, Anas;Jeha, Sima
通讯作者：
Jeha, Sima
影响因子：
8.8
作者：
Evans, N. T.;Wakefield, C. E.;Cohn, R. J.
通讯作者：
Cohn, R. J.
影响因子：
1.1
作者：
Piastra, Marco;Fognani, Giuliana;Franceschi, Alessia
通讯作者：
Franceschi, Alessia
癌症儿童中 COVID-19 的严重程度：英国儿科冠状病毒癌症监测项目的报告。
影响因子：
8.8
作者：
Millen GC;Arnold R;Cazier JB;Curley H;Feltbower RG;Gamble A;Glaser AW;Grundy RG;Lee LYW;McCabe MG;Phillips RS;Stiller CA;Várnai C;Kearns PR
通讯作者：
Kearns PR
影响因子：
8.8
作者：
Weller, D.;Vedsted, P.;Neal, R. D.
通讯作者：
Neal, R. D.