Rating scale measures are associated with Noldus EthoVision-XT video tracking of behaviors of children on the autism spectrum.
Rating scale measures are associated with Noldus EthoVision-XT video tracking of behaviors of children on the autism spectrum.
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DOI：
10.1186/2040-2392-5-15
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发表时间：
2014-02-18
期刊：
影响因子：
6.2
通讯作者：
Kim SY
中科院分区：
文献类型：
--
作者：
Cohen IL;Gardner JM;Karmel BZ;Kim SY
自闭症谱系障碍（ASD）儿童表现出不寻常的社会行为和重复行为。其中一些行为，例如，可以自动跟踪在区域中花费的时间或转弯速率/方向。与主观评级相比，自动跟踪具有几个优点，包括可靠性、提供的信息量和实验室之间的一致性，并且对于诊断、动物模型和治疗效果的客观评估可能具有重要意义。然而，它的有效性ASD还没有被检查。在这项探索性研究中，我们使用Noldus动物运动轨迹跟踪XT系统检查了评分量表数据与儿童运动自动跟踪之间的关联;即，不涉及人类观察者的跟踪。根据我们的观察和以前的研究，我们预测，在房间外围花费的时间将与自闭症的严重程度相关，转动的速度和方向将与刻板印象相关。在自闭症诊断观察量表-通用（ADOS-G）测试前和测试后3分钟，在自由游戏的情况下观察患有和不患有ASD的儿童。Noldus系统提供了转向的速度和方向，接近的延迟和在外围或母体附近花费的时间的测量。在总样本和ASD亚组中，适应不良的社会行为、刻板印象、自闭症严重程度和唤醒问题的严重程度与在外周花费的时间百分比的增加呈正相关。在ASD组中，适应性社交技能随着在外围花费的时间百分比的增加和接近父母的延迟时间的增加而下降。只有在没有ASD的那一组中，转向的速度和方向与刻板印象有关（向左转的速度越快，评级越差）。在ASD组中，从ADOS评估前的中性转向偏倚转变为ADOS评估后的强烈左转偏倚。在整个样本中，这种向左转的偏见与自闭症严重程度的测量有关。结果表明，自动跟踪产生有效和公正的信息，评估自闭症儿童。转向偏见是一个有趣的和未探索的措施有关自闭症。
Children with Autism Spectrum Disorder (ASD) show unusual social behaviors and repetitive behaviors. Some of these behaviors, e.g., time spent in an area or turning rate/direction, can be automatically tracked. Automated tracking has several advantages over subjective ratings including reliability, amount of information provided, and consistency across laboratories, and is potentially of importance for diagnosis, animal models and objective assessment of treatment efficacy. However, its validity for ASD has not been examined. In this exploratory study, we examined associations between rating scale data with automated tracking of children’s movements using the Noldus EthoVision XT system; i.e., tracking not involving a human observer. Based on our observations and previous research, we predicted that time spent in the periphery of the room would be associated with autism severity and that rate and direction of turning would be associated with stereotypies. Children with and without ASD were observed in a free-play situation for 3 min before and 3 min after Autism Diagnostic Observation Scale – Generic (ADOS-G) testing. The Noldus system provided measures of the rate and direction of turning, latency to approach and time spend near the periphery or the parent. Ratings of the severity of maladaptive social behaviors, stereotypies, autism severity, and arousal problems were positively correlated with increases in percent time spent in the periphery in the total sample and in the ASD subset. Adaptive social communication skills decreased with increases in the percentage of time spent in the periphery and increases in the latency to approach the parent in the ASD group. The rate and direction of turning was linked with stereotypies only in the group without ASD (the faster the rate of a turn to the left, the worse the rating). In the ASD group, there was a shift from a neutral turning bias prior to the ADOS assessment to a strong left turn bias after the ADOS assessment. In the entire sample, this left turn bias was associated with measures of autism severity. Results suggest that automated tracking yields valid and unbiased information for assessing children with autism. Turning bias is an interesting and unexplored measure related to autism.
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