Retinal nerve fiber layer atrophy is associated with visual field loss over time in glaucoma suspect and glaucomatous eyes.
Retinal nerve fiber layer atrophy is associated with visual field loss over time in glaucoma suspect and glaucomatous eyes.
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DOI：
10.1016/j.ajo.2012.07.005
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发表时间：
2013-01
影响因子：
4.2
通讯作者：
Huang, David
中科院分区：
文献类型：
--
作者：
Sehi, Mitra;Zhang, Xinbo;Greenfield, David S.;Chung, Yunsuk;Wollstein, Gadi;Francis, Brian A.;Schuman, Joel S.;Varma, Rohit;Huang, David
前瞻性比较在疑似青光眼和视野前青光眼和视野青光眼患者中使用时域光学相干断层扫描（OCT）识别的进行性视网膜神经纤维层厚度（RNFL）萎缩检测与使用标准自动视野检查（SAP）的视野进展。前瞻性纵向临床试验随访≥2年的合格患眼每6个月接受一次时域OCT和SAP。视野进展的发生被定义为随着时间的推移，第一次随访达到显著（p<0.05）负视野指数（VFI）斜率。RNFL进展/改善定义为随时间推移的显著负/正斜率。特异性定义为既没有进展也没有改善的眼睛数量除以没有进展的眼睛数量。使用单变量和多变量模型计算考克斯比例风险比（HR），以RNFL损失作为时间依赖性协变量。包括310例可疑青光眼和视野前青光眼，177例视野性青光眼。89只眼显示视野进展，101只眼显示RNFL进展。在这89只眼中检测到视野进展的平均时间为35±13个月;在这101只眼中检测到RNFL进展的平均时间为36±13个月。在多变量考克斯模型中，平均和上级RNFL丢失与整个队列中随后的VFI丢失相关（每10μm丢失，HR= 1.38，p =0.03; HR=1.20，p=0.01）。在整个队列的487只眼中，42只VFI显著改善，55只RNFL显著改善（特异性分别为91.4%和88.7%）。疑似青光眼和青光眼性眼的结构进展与功能进展相关。平均和上级RNFL厚度可以预测随后的SAP丢失。
To prospectively compare detection of progressive retinal nerve fiber layer thickness (RNFL) atrophy identified using time-domain optical coherence tomography (OCT) with visual field progression using standard automated perimetry (SAP) in glaucoma suspect and preperimetric glaucoma and perimetric glaucoma patients. Prospective longitudinal clinical trial Eligible eyes with ≥2 years of follow-up underwent time-domain OCT and SAP every 6 months. The occurrence of visual field progression was defined as the first follow-up visit reaching a significant (p<0.05) negative visual field index (VFI) slope over time. RNFL progression/improvement was defined as a significant negative/positive slope over time. Specificity was defined as the number of eyes with neither progression nor improvement, divided by the number of eyes without progression. Cox proportional hazard ratios (HR) were calculated using univariate and multivariate models with RNFL loss as a time-dependent covariate. 310 glaucoma suspect and preperimetric glaucoma, and 177 perimetric glaucoma eyes were included. Eighty-nine eyes showed visual field progression and 101 eyes showed RNFL progression. The average time to detect visual field progression in those 89 eyes was 35±13 months; and to detect RNFL progression in those 101 eyes was 36±13 months. In multivariate Cox models, average and superior RNFL losses were associated with subsequent VFI loss in the entire cohort (every 10μm loss, HR=1.38,p=0.03; HR=1.20, p=0.01 respectively). Among the entire cohort of 487 eyes, 42 had significant VFI improvement and 55 had significant RNFL improvement (specificity 91.4% and 88.7%, respectively). Structural progression is associated with functional progression in glaucoma suspect and glaucomatous eyes. Average and superior RNFL thickness may predict subsequent SAP loss.
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DOI：
10.1007/s00417-008-0808-5
发表时间：
2008-08-01
影响因子：
2.7
作者：
Falsini, Benedetto;Marangoni, Dario;Colotto, Alberto
通讯作者：
Colotto, Alberto
影响因子：
4.2
作者：
Boden, C;Blumenthal, EZ;Sample, PA
通讯作者：
Sample, PA
影响因子：
--
作者：
Medeiros, Felipe A.;Alencar, Luciana M.;Zangwill, Linda M.;Bowd, Christopher;Sample, Pamela A.;Weinreb, Robert N.
通讯作者：
Weinreb, Robert N.
影响因子：
3.9
作者：
Mansouri, K.;Leite, M. T.;Weinreb, R. N.
通讯作者：
Weinreb, R. N.
影响因子：
13.7
作者：
Leung, Christopher Kai Shun;Liu, Shu;Lam, Dennis Shun Chiu
通讯作者：
Lam, Dennis Shun Chiu