Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation.
Loneliness predicts pain, depression, and fatigue: understanding the role of immune dysregulation.
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DOI：
10.1016/j.psyneuen.2012.11.016
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发表时间：
2013-08
影响因子：
3.7
通讯作者：
Kiecolt-Glaser, Janice K.
中科院分区：
文献类型：
--
作者：
Jaremka, Lisa M.;Fagundes, Christopher P.;Glaser, Ronald;Bennett, Jeanette M.;Malarkey, William B.;Kiecolt-Glaser, Janice K.
关键词：
疼痛、抑郁和疲劳症状群是一个重要的健康问题。孤独是这些症状的常见风险因素。人们对孤独与症状群之间的生理机制知之甚少;免疫失调是一个有希望的候选者。潜伏性疱疹病毒再激活，这是反映了疱疹病毒抗体滴度升高，提供了一个窗口，免疫失调。巨细胞病毒（CMV）和EB病毒（EBV）是两种常见的疱疹病毒。参与者是200名乳腺癌幸存者，他们在研究时接受了2个月至3年的治疗。他们完成了问卷调查，并提供了一个血液样本，用于CMV和EBV抗体滴度测定。孤独的参与者比那些感觉社会联系更紧密的人经历了更多的痛苦，抑郁和疲劳。孤独的参与者也有更高的CMV抗体滴度，这反过来又与更高水平的疼痛，抑郁和疲劳症状群相关。与预期相反，EBV抗体滴度与孤独或症状群无关。疼痛、抑郁和疲劳症状群是一个值得注意的临床问题，尤其是在癌症幸存者中。因此，了解这些症状的危险因素是很重要的。目前的研究表明，孤独会增加免疫失调以及疼痛、抑郁和疲劳症状群的风险。目前的数据还提供了一个一瞥通过孤独可能影响健康的途径。
The pain, depression, and fatigue symptom cluster is an important health concern. Loneliness is a common risk factor for these symptoms. Little is known about the physiological mechanisms linking loneliness to the symptom cluster; immune dysregulation is a promising candidate. Latent herpesvirus reactivation, which is reflected by elevated herpesvirus antibody titers, provides a window into immune dysregulation. Cytomegalovirus (CMV) and Epstein-Barr virus (EBV) are two common herpesviruses. Participants were 200 breast cancer survivors who were 2 months to 3 years post-treatment at the time of the study. They completed questionnaires and provided a blood sample that was assayed for CMV and EBV antibody titers. Lonelier participants experienced more pain, depression, and fatigue than those who felt more socially connected. Lonelier participants also had higher CMV antibody titers which, in turn, were associated with higher levels of the pain, depression, and fatigue symptom cluster. Contrary to expectations, EBV antibody titers were not associated with either loneliness or the symptom cluster. The pain, depression, and fatigue symptom cluster is a notable clinical problem, especially among cancer survivors. Accordingly, understanding the risk factors for these symptoms is important. The current study suggests that loneliness enhances risk for immune dysregulation and the pain, depression, and fatigue symptom cluster. The present data also provide a glimpse into the pathways through which loneliness may impact health.
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影响因子：
3.1
作者：
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通讯作者：
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