Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.

Foxj1 expressing ependymal cells do not contribute new cells to sites of injury or stroke in the mouse forebrain.
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DOI:
10.1038/s41598-018-19913-x
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发表时间:
2018-01-29
期刊:
影响因子:
4.6
通讯作者:
Ghashghaei HT
Ghashghaei HT
中科院分区:
综合性期刊3区
文献类型:
--
作者:
Muthusamy N;Brumm A;Zhang X;Carmichael ST;Ghashghaei HT

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The stem cell source of neural and glial progenitors in the periventricular regions of the adult forebrain has remained uncertain and controversial. Using a cell specific genetic approach we rule out Foxj1+ ependymal cells as stem cells participating in neurogenesis and gliogenesis in response to acute injury or stroke in the mouse forebrain. Non stem- and progenitor-like responses of Foxj1+ ependymal cells to injury and stroke remain to be defined and investigated.
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