Pattern of access determines influence of junk food diet on cue sensitivity and palatability.
Pattern of access determines influence of junk food diet on cue sensitivity and palatability.
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DOI：
10.1016/j.appet.2017.12.009
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发表时间：
2018-04-01
期刊：
影响因子：
5.4
通讯作者：
Murphy NP
中科院分区：
文献类型：
--
作者：
Kosheleff AR;Araki J;Hsueh J;Le A;Quizon K;Ostlund SB;Maidment NT;Murphy NP
就像药物成瘾一样，与美味食物相关的线索会引发食物寻求，即使是在吃饱的时候。然而，对食物相关线索的激励影响的易感性是否是暴饮暴食的诱发因素或不良饮食的后果很难确定。使用啮齿动物模型，我们探讨了是否一个非常可口的“垃圾食品”的饮食影响反应的奖励配对线索在巴甫洛夫仪器转移测试，使用甜炼乳（SCM）作为奖励。通过分析舔微观结构，还评估了SCM消费的享乐影响。为了探索垃圾食品暴露的模式和持续时间的影响，我们为大鼠提供了任意的常规食物（对照）或食物加垃圾食品，每天2或24小时，持续1，3或6周。我们还研究了个体对体重增加的敏感性与这些措施的关系。大鼠提供24小时访问垃圾食品的饮食不敏感的SCM配对线索的激励作用时，测试满足，即使他们的享乐经验奖励消费后，是类似的控制。相比之下，大鼠提供了限制，2小时获得垃圾食品表现出的线索泛化表型在饱足的条件下，增加活力的SCM配对的线索，和线索先前没有配对的奖励的压力。这些动物的享乐反应也显著高于对照组。这些数据表明，垃圾食品暴露的模式不同地改变了美味食物的享乐影响和对环境中的线索的激励影响的敏感性，以促进饱足时的寻食行为，这可能是理解暴饮暴食和肥胖的结果。
Like drug addiction, cues associated with palatable foods can trigger food-seeking, even when sated. However, whether susceptibility to the motivating influence of food-related cues is a predisposing factor in overeating or a consequence of poor diet is difficult to determine in humans. Using a rodent model, we explored whether a highly palatable ‘junk food’ diet impacts responses to reward-paired cues in a Pavlovian-to-instrumental transfer test, using sweetened condensed milk (SCM) as the reward. The hedonic impact of SCM consumption was also assessed by analyzing licking microstructure. To probe the effects of pattern and duration of junk food exposure, we provided rats with either regular chow ad libitum (controls) or chow plus access to junk food for either 2 or 24 h per day for 1, 3, or 6 weeks. We also examined how individual susceptibility to weight gain related to these measures. Rats provided 24 h access to the junk food diet were insensitive to the motivational effects of a SCM-paired cue when tested sated even though their hedonic experience upon reward consumption was similar to controls. In contrast, rats provided restricted, 2 h access to junk food exhibited a cue generalization phenotype under sated conditions, lever-pressing with increased vigor in response to both a SCM-paired cue, and a cue not previously paired with reward. Hedonic response was also significantly higher in these animals relative to controls. These data demonstrate that the pattern of junk food exposure differentially alters the hedonic impact of palatable foods and susceptibility to the motivating influence of cues in the environment to promote food-seeking actions when sated, which may be consequential for understanding overeating and obesity.
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DOI：
10.1038/npp.2009.187
发表时间：
2010-02
期刊：
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology
影响因子：
--
作者：
通讯作者：
--
影响因子：
4.9
作者：
Boggiano, M. M.;Dorsey, J. R.;Murdaugh, D. L.
通讯作者：
Murdaugh, D. L.
影响因子：
2.9
作者：
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通讯作者：
Pendergrass, David C.
影响因子：
6.9
作者：
Davis, Caroline A.;Levitan, Robert D.;Kennedy, James L.
通讯作者：
Kennedy, James L.
影响因子：
6.9
作者：
Colles, Susan L.;Dixon, John B.;O'Brien, Paul E.
通讯作者：
O'Brien, Paul E.