Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution.
Symptoms and medication use in children with asthma and traffic-related sources of fine particle pollution.
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DOI：
10.1289/ehp.0800335
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发表时间：
2009-07
影响因子：
10.4
通讯作者：
Leaderer BP
中科院分区：
文献类型：
--
作者：
Gent JF;Koutrakis P;Belanger K;Triche E;Holford TR;Bracken MB;Leaderer BP
暴露于环境细颗粒物[颗粒物直径≤2.5 μm (PM2.5)]是哮喘加重的潜在因素。国家空气质量颗粒标准考虑的是总质量，而不是成分或来源，可能无法防止与特定成分有关的健康影响。我们研究了哮喘儿童每日接触细颗粒成分和来源与症状和药物使用之间的关系。4-12岁的哮喘儿童（n = 149）被纳入一项为期一年的研究。我们分析了颗粒样品的微量元素（x射线荧光）和元素碳（光反射率）。通过因子分析/源分配，我们确定了颗粒源（如机动车排放）并量化了每日贡献。症状和药物使用记录在研究日记中。重复测量逻辑回归模型检验了健康结果与颗粒暴露之间的关系，如元素浓度和来源贡献。平均PM2.5的一半以上归因于与交通有关的来源——机动车（42%）和道路粉尘（12%）。症状和吸入器使用增加的可能性在平均暴露于交通相关源或其基本成分3天的情况下最大，范围从机动车颗粒每增加5 μg/m3，气喘的可能性增加10%到道路粉尘增加，呼吸短促的可能性增加28%。其他来源和PM2.5都与健康风险增加无关。将呼吸道健康影响与特定颗粒污染成分或来源联系起来，对于保护公众健康的努力至关重要。我们将哮喘儿童的症状和吸入器使用风险增加与接触交通相关的细颗粒物联系起来。
Exposure to ambient fine particles [particulate matter ≤ 2.5 μm diameter (PM2.5)] is a potential factor in the exacerbation of asthma. National air quality particle standards consider total mass, not composition or sources, and may not protect against health impacts related to specific components. We examined associations between daily exposure to fine particle components and sources, and symptoms and medication use in children with asthma. Children with asthma (n = 149) 4–12 years of age were enrolled in a year-long study. We analyzed particle samples for trace elements (X-ray fluorescence) and elemental carbon (light reflectance). Using factor analysis/source apportionment, we identified particle sources (e.g., motor vehicle emissions) and quantified daily contributions. Symptoms and medication use were recorded on study diaries. Repeated measures logistic regression models examined associations between health outcomes and particle exposures as elemental concentrations and source contributions. More than half of mean PM2.5 was attributed to traffic-related sources motor vehicles (42%) and road dust (12%). Increased likelihood of symptoms and inhaler use was largest for 3-day averaged exposures to traffic-related sources or their elemental constituents and ranged from a 10% increased likelihood of wheeze for each 5-μg/m3 increase in particles from motor vehicles to a 28% increased likelihood of shortness of breath for increases in road dust. Neither the other sources identified nor PM2.5 alone was associated with increased health outcome risks. Linking respiratory health effects to specific particle pollution composition or sources is critical to efforts to protect public health. We associated increased risk of symptoms and inhaler use in children with asthma with exposure to traffic-related fine particles.
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影响因子：
10.4
作者：
Hong YC;Hwang SS;Kim JH;Lee KH;Lee HJ;Lee KH;Yu SD;Kim DS
通讯作者：
Kim DS
儿童早期下呼吸道疾病和空气污染。
影响因子：
10.4
作者：
Hertz-Picciotto, Irva;Baker, Rebecca James;Yap, Poh-Sin;Dostal, Miroslav;Joad, Jesse P;Lipsett, Michael;Greenfield, Teri;Herr, Caroline E W;Benes, Ivan;Shumway, Robert H;Pinkerton, Kent E;Sram, Radim
通讯作者：
Sram, Radim
DOI：
10.1038/sj.jea.7500262
发表时间：
2003-03-01
期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
--
作者：
Cyrys, J;Heinrich, J;Brunekreef, B
通讯作者：
Brunekreef, B
DOI：
10.1080/09603120601093642
发表时间：
2006-12-01
影响因子：
3.2
作者：
Johnston, Fay H.;Webby, Rosalind J.;Halpin, Stephen J.
通讯作者：
Halpin, Stephen J.
DOI：
10.1097/ede.0b013e3181812bb7
发表时间：
2008-09
期刊：
Epidemiology (Cambridge, Mass.)
影响因子：
--
作者：
Franklin M;Koutrakis P;Schwartz P
通讯作者：
Schwartz P