Increased cortical activity in binge drinkers during working memory task: a preliminary assessment through a functional magnetic resonance imaging study.
Increased cortical activity in binge drinkers during working memory task: a preliminary assessment through a functional magnetic resonance imaging study.
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DOI：
10.1371/journal.pone.0062260
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Verbanck P
中科院分区：
文献类型：
--
作者：
Campanella S;Peigneux P;Petit G;Lallemand F;Saeremans M;Noël X;Metens T;Nouali M;De Tiège X;De Witte P;Ward R;Verbanck P
大脑功能障碍是慢性酒精滥用者和酗酒者的共同特征。在这里，我们的目的是研究是否，在等同的行为表现水平，狂饮者表现出增加的神经活动，而执行简单的认知任务。32名参与者（16名酗酒者和16名匹配的对照组）在执行n-back工作记忆任务时使用功能性磁共振成像（fMRI）进行扫描。在控制归零（N 0）条件下，当数字“2”显示时，要求受试者用右手按下按钮。在两回（N2）条件下，当显示的数字与两次试验前显示的数字相同时，受试者必须按下按钮。功能磁共振成像分析显示，即使行为表现相似，酗酒者的前补充运动区的双侧活动也高于对照组。此外，酗酒者在进行N2记忆任务时，每次饮酒的次数与背内侧前额叶皮层的较高活动之间，以及每周饮酒次数与小脑、丘脑和小脑的较高活动之间，都表现出特定的正相关。酗酒可能导致酗酒者大脑的代偿性变化，从而促进正常的行为表现。大脑反应的这些变化可能被认为是发展成人物质使用障碍的脆弱性因素。
Cerebral dysfunction is a common feature of both chronic alcohol abusers and binge drinkers. Here, we aimed to study whether, at equated behavioral performance levels, binge drinkers exhibited increased neural activity while performing simple cognitive tasks. Thirty-two participants (16 binge drinkers and 16 matched controls) were scanned using functional magnetic resonance imaging (fMRI) while performing an n-back working memory task. In the control zero-back (N0) condition, subjects were required to press a button with the right hand when the number “2″ was displayed. In the two-back (N2) condition, subjects had to press a button when the displayed number was identical to the number shown two trials before. fMRI analyses revealed higher bilateral activity in the pre-supplementary motor area in binge drinkers than matched controls, even though behavioral performances were similar. Moreover, binge drinkers showed specific positive correlations between the number of alcohol doses consumed per occasion and higher activity in the dorsomedial prefrontal cortex, as well as between the number of drinking occasions per week and higher activity in cerebellum, thalamus and insula while performing the N2 memory task. Binge alcohol consumption leads to possible compensatory cerebral changes in binge drinkers that facilitate normal behavioral performance. These changes in cerebral responses may be considered as vulnerability factors for developing adult substance use disorders.
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影响因子：
16.2
作者：
Dobbins, IG;Foley, H;Wagner, AD
通讯作者：
Wagner, AD
影响因子：
5.7
作者：
Ishai, A;Haxby, JV;Ungerleider, LG
通讯作者：
Ungerleider, LG
DOI：
10.1097/01.alc.0000164381.67723.76
发表时间：
2005-05-01
期刊：
ALCOHOL-CLINICAL AND EXPERIMENTAL RESEARCH
影响因子：
--
作者：
Harford, TC;Grant, BF;Chen, CM
通讯作者：
Chen, CM
影响因子：
4.4
作者：
Keller, Stefan;Maddock, Jason E.;Basler, Heinz-Dieter
通讯作者：
Basler, Heinz-Dieter
影响因子：
56.9
作者：
Bechara, A;Damasio, H;Damasio, AR
通讯作者：
Damasio, AR