A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms.
A Model to Investigate the Impact of Farm Practice on Antimicrobial Resistance in UK Dairy Farms.
复制标题
一个调查农场实践对英国奶牛场抗菌素耐药性影响的模型。
DOI：
10.1007/s11538-021-00865-9
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发表时间：
2021-03-01
影响因子：
3.5
通讯作者：
Gomes RL
中科院分区：
文献类型：
--
作者：
Lanyon CW;King JR;Stekel DJ;Gomes RL
畜牧业中抗生素使用对生态和人类健康的影响以及相关的抗菌素耐药性（AMR）知之甚少。在许多国家，减少农业中抗生素的总体使用或停止或尽量减少人类关键抗生素的使用存在相当大的压力。然而，更细致的方法将考虑使用不同抗生素类别的不同影响;例如，不知道减少抑菌或溶菌抗生素类别的使用是否会更有价值。我们已经开发了一个常微分方程模型来调查的影响，农场的做法对AMR的传播和持久性的牛奶浆罐环境。我们模拟了泥浆中溶菌抗生素和抑菌抗生素的化学命运及其对细菌种群的影响，这些细菌能够对这两种类型的抗生素产生抗性。通过我们的分析，我们发现改变泥浆罐清空的速度可能会根据条件将多重耐药细菌的增殖延迟长达五年。这一发现对农业实践和影响废物管理实践的政策具有影响。我们还发现，在我们的模型中，多药耐药性的发展对溶菌抗生素的使用特别敏感，而不是抑菌抗生素，这可能是控制溶菌抗生素在农业中使用的原因。
The ecological and human health impact of antibiotic use and the related antimicrobial resistance (AMR) in animal husbandry is poorly understood. In many countries, there has been considerable pressure to reduce overall antibiotic use in agriculture or to cease or minimise use of human critical antibiotics. However, a more nuanced approach would consider the differential impact of use of different antibiotic classes; for example, it is not known whether reduced use of bacteriostatic or bacteriolytic classes of antibiotics would be of greater value. We have developed an ordinary differential equation model to investigate the effects of farm practice on the spread and persistence of AMR in the dairy slurry tank environment. We model the chemical fate of bacteriolytic and bacteriostatic antibiotics within the slurry and their effect on a population of bacteria, which are capable of resistance to both types of antibiotic. Through our analysis, we find that changing the rate at which a slurry tank is emptied may delay the proliferation of multidrug-resistant bacteria by up to five years depending on conditions. This finding has implications for farming practice and the policies that influence waste management practices. We also find that, within our model, the development of multidrug resistance is particularly sensitive to the use of bacteriolytic antibiotics, rather than bacteriostatic antibiotics, and this may be cause for controlling the usage of bacteriolytic antibiotics in agriculture.
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影响因子：
2.8
作者：
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通讯作者：
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