Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary-care hospital: A 6-year retrospective study.
Clinical characteristics of patients with chronic eosinophilic pneumonia in a Chinese tertiary-care hospital: A 6-year retrospective study.
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中国三级医院慢性嗜酸细胞性肺炎患者的临床特征：6年回顾性研究
DOI：
10.1111/crj.13448
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发表时间：
2022-01
期刊：
影响因子：
--
通讯作者：
中科院分区：
文献类型：
--
作者：
慢性嗜酸性粒细胞性肺炎（CEP）是一种病因不明的罕见疾病。由于CEP症状缺乏特异性，临床医生在确定其诊断方面缺乏经验。总结CEP患者的临床资料，提高对CEP的认识，减少误诊。收集2013年5月至2019年5月解放军总医院病理诊断为CEP的患者资料，回顾性分析临床表现、影像学特征、病理特征及治疗方法。20例患者确诊为CEP，其中男6例，女14例。平均年龄47.0±10.2岁。主要临床表现为咳嗽、呼吸困难。CEP的平均持续时间为15.5±11.5个月。外周血中嗜酸性粒细胞平均占18.9±17.8%，支气管肺泡灌洗液中嗜酸性粒细胞平均占41.5±19.4%。主要影像学特征为斑片状阴影和实变阴影。支气管镜检查最常见的表现是支气管粘膜充血和水肿。2例患者气管内膜颗粒状突出。组织学检查显示大量嗜酸性粒细胞浸润。所有患者经强的松治疗后均有改善。CEP发病隐匿，临床表现缺乏特异性。典型的影像学表现为肺浸润的周围和胸膜下分布。一些患者外周血中嗜酸性粒细胞比例正常，但大多数患者BALF中嗜酸性粒细胞数量增加，这有助于CEP的诊断。当鉴别诊断困难时，活检是必要的。全身糖皮质激素是有效的。
Chronic eosinophilic pneumonia (CEP) is a rare disease with unknown etiology. Due to lack of specificity of CEP symptoms, clinicians are not experienced in establishing its diagnosis. To summarize the clinical data of CEP patients to improve the understanding of CEP and reduce misdiagnosis. Data of patients pathologically diagnosed with CEP in the PLA General Hospital between May 2013 and May 2019 were collected, and clinical manifestations, imaging characteristics, pathological features, and treatment were retrospectively analyzed. Twenty patients, including 6 males and 14 females, were diagnosed with CEP. The average age was 47.0 ± 10.2 years. The main clinical manifestations were cough and dyspnea. The average duration of CEP was 15.5 ± 11.5 months. The average proportion of eosinophils in the peripheral blood was 18.9 ± 17.8%, and the average proportion of eosinophils in the bronchoalveolar lavage fluid was 41.5 ± 19.4%. The main imaging features were patchy shadows and consolidation shadows. The most common manifestations on bronchoscopic examination were congestion and edema of the bronchial mucosa. Two patients had granular protrusions of the endotracheal membrane. Histological examination indicated infiltration of numerous eosinophils. All patients improved after prednisone therapy. CEP onset is insidious, and clinical manifestations lack specificity. Typical imaging features are peripheral and subpleural distribution of lung infiltrates. Some patients have a normal proportion of eosinophils in the peripheral blood, but most have an increased number of eosinophils in the BALF, which contributes to CEP diagnosis. A biopsy is necessary when differential diagnosis is difficult. A systemic glucocorticoid is effective.
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影响因子：
2.8
作者：
Watanabe, Naoto;Hirata, Akira;Fukuda, Takeshi
通讯作者：
Fukuda, Takeshi
影响因子：
2.6
作者：
Cottin, Vincent;Cordier, Jean-Francois
通讯作者：
Cordier, Jean-Francois
影响因子：
158.5
作者：
CARRINGT.CB;ADDINGTO.WW;GAENSLER, EA
通讯作者：
GAENSLER, EA
影响因子：
4.2
作者：
Boudou, Laurence;Alexandre, Christian;Pallot-Prade, Beatrice
通讯作者：
Pallot-Prade, Beatrice
影响因子：
3.7
作者：
Marchand E;Cordier JF
通讯作者：
Cordier JF