Free-running circadian period in adolescents and adults.
Free-running circadian period in adolescents and adults.
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青少年和成人自由运行的昼夜节律期。
DOI：
10.1111/jsr.12678
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发表时间：
2018-10
影响因子：
4.4
通讯作者：
Eastman CI
中科院分区：
文献类型：
--
作者：
Crowley SJ;Eastman CI
在青春期（第二个十年），睡眠时间会推迟。这一趋势在20岁左右逆转，并继续提前进入成年期。目前的分析研究了一个假设，即青春期后期（14-17岁）与成年期（30-45岁）相比，自由运行的昼夜节律周期更长，这是睡眠时间差异的原因。性别和血统也进行了检查，因为以前的报告发现，妇女和非洲裔美国人的祖先有较短的自由运行时间。在3.4天内使用超昼夜暗光方案（2小时黑暗/睡眠，2小时昏暗室内光（~20勒克斯）/觉醒）测量昼夜节律周期。昏暗的光褪黑激素发病前后的超昼夜协议，从昼夜节律周期的推导。与我们的假设相反，我们发现青少年和成年人的自由运行昼夜节律周期相似。与其他血统的成年人相比，非洲裔美国人的自由运行昼夜节律周期较短。在青少年组中没有发现这种血统差异。最后，我们观察到一个非显着的趋势，较短的自由运行的昼夜节律周期的女性相比，男性。这些数据表明，青春期后期后与年龄相关的昼夜节律变化不能解释睡眠时间差异。这些数据为与祖先有关的时期差异提供了进一步的支持，特别是在成年人中。非裔美国人和其他祖先之间的昼夜节律周期是否在发育后期出现巨大差异，应该加以探讨。
Sleep timing shifts later during adolescence (second decade). This trend reverses at ~20 years and continues to shift earlier into adulthood. The current analysis examined the hypothesis that a longer free-running circadian period during late adolescence (14–17 years) compared to adulthood (30–45 years) accounts for sleep timing differences. Sex and ancestry were also examined because previous reports find that women and those with African-American ancestry have shorter free-running periods. Circadian period was measured using an ultradian dark-light protocol (2h dark/sleep, 2h dim room light (~20 lux)/wake) over 3.4 days. Dim light melatonin onsets were measured before and after the ultradian protocol, from which circadian period was derived. In contrast to our hypothesis, we found that that free-running circadian period was similar in adolescents and adults. African-American adults had shorter free-running circadian periods compared to adults of other ancestries. This ancestry difference was not seen in the adolescent group. Finally, we observed a non-significant trend for shorter free-running circadian periods in females compared to males. These data suggest that age-related changes in circadian period after late adolescence do not account for sleep timing differences. These data provide further support for ancestry-related differences in period, particularly in adults. Whether the large difference in circadian period between African American and other ancestries emerge later in development should be explored.
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DOI：
10.1196/annals.1308.032
发表时间：
2004-01-01
期刊：
ADOLESCENT BRAIN DEVELOPMENT: VULNERABILITIES AND OPPORTUNITIES
影响因子：
--
作者：
Carskadon, MA;Acebo, C;Jenni, OG
通讯作者：
Jenni, OG
DOI：
10.1073/pnas.1010666108
发表时间：
2011-09-13
影响因子：
11.1
作者：
Duffy, Jeanne F.;Cain, Sean W.;Czeisler, Charles A.
通讯作者：
Czeisler, Charles A.
影响因子：
--
作者：
Kripke DF;Elliott JA;Youngstedt SD;Rex KM
通讯作者：
Rex KM
影响因子：
3.7
作者：
Crowley, Stephanie J.;Van Reen, Eliza;Carskadon, Mary A.
通讯作者：
Carskadon, Mary A.
影响因子：
1.2
作者：
RADLOFF L S
通讯作者：
RADLOFF L S