Mechanical and acid neutralizing properties and bacteria inhibition of amorphous calcium phosphate dental nanocomposite.
Mechanical and acid neutralizing properties and bacteria inhibition of amorphous calcium phosphate dental nanocomposite.
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DOI：
10.1002/jbm.b.31834
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发表时间：
2011-07
影响因子：
3.4
通讯作者：
Xu, Hockin H. K.
中科院分区：
文献类型：
--
作者：
Moreau, Jennifer L.;Sun, Limin;Chow, Laurence C.;Xu, Hockin H. K.
关键词：
牙科复合材料不妨碍细菌定植和菌斑形成。修复体边缘的龋坏是更换现有修复体的常见原因，占所有修复体的50%至70%。本研究的目的是研究填料水平对含有无定形磷酸钙（NACP）纳米颗粒的纳米复合材料的影响，并研究其承载和酸中和性能以及细菌抑制作用。通过喷雾干燥技术合成了粒径为116纳米的NACP，并将其掺入树脂中。具有10 - 30%NACP填料的纳米复合材料的弯曲强度与商业混合复合材料的强度相匹配（p > 0.1）。具有40%NACP的纳米复合材料匹配微填充复合材料的强度，其是树脂改性的玻璃离聚物的2倍。纳米复合材料与40%NACP中和乳酸溶液的pH值为4，迅速增加pH值为5.69，在10分钟。相比之下，商业控制pH值保持在4附近。使用变形链球菌，琼脂盘扩散试验显示商业对照品无抑菌圈。而NACP含量为40%的纳米复合材料的抑菌圈为（2.5 ± 0.7）mm。结晶紫染色显示S.纳米复合材料上的变形杆菌覆盖率是商业复合材料上的1/4。总之，新型磷酸钙纳米复合材料的机械性能与商业复合材料相匹配，并迅速中和pH 4的乳酸。纳米复合材料似乎适度降低了S。变形菌生长，需要进一步研究以获得强的抗菌性能。新的纳米复合材料可能有潜力减少继发龋和修复断裂，这是牙洞修复面临的两个主要挑战。
Dental composites do not hinder bacteria colonization and plaque formation. Caries at the restoration margins is a frequent reason for replacement of existing restorations, which accounts for 50 to 70% of all restorations. The objectives of this study were to examine the filler level effect on nanocomposite containing nanoparticles of amorphous calcium phosphate (NACP) and investigate the load-bearing and acid-neutralizing properties and bacteria inhibition. NACP with 116-nm particle size were synthesized via a spray-drying technique and incorporated into a resin. Flexural strength of nanocomposite with 10 to 30% NACP fillers matched the strength of a commercial hybrid composite (p > 0.1). Nanocomposite with 40% NACP matched the strength of a microfill composite, which was 2-fold that of a resin-modified glass ionomer. Nanocomposite with 40% NACP neutralized a lactic acid solution of pH 4 by rapidly increasing the pH to 5.69 in 10 min. In contrast, the commercial controls had pH staying at near 4. Using Streptoccocus mutans, an agar disk-diffusion test showed no inhibition zone for commercial controls. In contrast, the inhibition zone was (2.5 ± 0.7) mm for nanocomposite with 40% NACP. Crystal violet staining showed that S. mutans coverage on nanocomposite was 1/4 that on commercial composite. In conclusion, novel calcium–phosphate nanocomposite matched the mechanical properties of commercial composite and rapidly neutralized lactic acid of pH 4. The nanocomposite appeared to moderately reduce the S. mutans growth, and further study is needed to obtain strong antimicrobial properties. The new nanocomposite may have potential to reduce secondary caries and restoration fracture, two main challenges facing tooth cavity restorations.
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影响因子：
5
作者：
Lim, BS;Ferracane, JL;Condon, JR
通讯作者：
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影响因子：
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影响因子：
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