Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.
Prenatal exposure to organophosphorus pesticides and childhood neurodevelopmental phenotypes.
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DOI：
10.1016/j.envres.2017.07.023
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发表时间：
2017-10
影响因子：
8.3
通讯作者：
Engel SM
中科院分区：
文献类型：
--
作者：
Furlong MA;Herring A;Buckley JP;Goldman BD;Daniels JL;Engel LS;Wolff MS;Chen J;Wetmur J;Barr DB;Engel SM
在不同的队列中，产前接触有机磷农药(OPs)与不同的神经发育结局有关。表型方法可以通过整合不同级别的信息并解释神经发育结果的复杂相关结构来解决其中的一些差异。此外，贝叶斯分层建模可以解释共线共曝光造成的混淆。我们使用这个框架来检验孕期招募的404对母亲/婴儿的队列中，产前暴露于有机磷农药与6-9岁时评估的行为、执行功能和智商之间的关系。我们通过因子分析得出了神经发育的表型，并在暴露混合物的贝叶斯分层模型中估计了OP代谢物和这些表型之间的关联。我们报告了七个因素：1)冲动和外化，2)执行功能，3)内化，4)知觉推理，5)适应性，6)处理速度，7)言语智力。这些和工作记忆指数一起被标准化和标度，因此积极的值反映积极的属性，而负值代表不利的结果。标准化的二甲基磷代谢产物与内化因子分呈负相关(95%CI−为0.26，0.00)，与执行功能因子分呈正相关(95%CI为0.04，0.31)。标准化二乙基磷酸代谢产物与工作记忆指数呈负相关(95%CI−为0.33，−为0.03)。与因子分数的关联通常比与个别乐器特定项目的关联更强和更精确。通过整合不同尺度的信息来降低维度和提高精度，结果的因子分析可能会在儿童神经发育的病因学研究中提供一些优势。
Prenatal exposure to organophosphorus pesticides (OPs) has been associated with different neurodevelopmental outcomes across different cohorts. A phenotypic approach may address some of these differences by incorporating information across scales and accounting for the complex correlational structure of neurodevelopmental outcomes. Additionally, Bayesian hierarchical modeling can account for confounding by collinear co-exposures. We use this framework to examine associations between prenatal exposure to OPs and behavior, executive functioning, and IQ assessed at age 6–9 years in a cohort of 404 mother/infant pairs recruited during pregnancy. We derived phenotypes of neurodevelopment with a factor analysis, and estimated associations between OP metabolites and these phenotypes in Bayesian hierarchical models for exposure mixtures. We report seven factors: 1) Impulsivity and Externalizing, 2) Executive Functioning, 3) Internalizing, 4) Perceptual Reasoning, 5) Adaptability, 6) Processing Speed, and 7) Verbal Intelligence. These, along with the Working Memory Index, were standardized and scaled so that positive values reflected positive attributes and negative values represented adverse outcomes. Standardized dimethylphosphate metabolites were negatively associated with Internalizing factor scores ( , 95% CI − 0.26, 0.00) but positively associated with Executive Functioning factor scores ( , 95% CI 0.04, 0.31). Standardized diethylphosphate metabolites were negatively associated with the Working Memory Index ( , 95% CI − 0.33, − 0.03). Associations with factor scores were generally stronger and more precise than associations with individual instrument-specific items. Factor analysis of outcomes may provide some advantages in etiological studies of childhood neurodevelopment by incorporating information across scales to reduce dimensionality and improve precision.
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影响因子：
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DOI：
10.1198/016214507000000554
发表时间：
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影响因子：
3.7
作者：
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DOI：
10.1038/sj.jea.7500322
发表时间：
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期刊：
JOURNAL OF EXPOSURE ANALYSIS AND ENVIRONMENTAL EPIDEMIOLOGY
影响因子：
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作者：
Bravo, R;Caltabiano, LM;Barr, DB
通讯作者：
Barr, DB