Bushen Huoxue Recipe Alleviates Implantation Loss in Mice by Enhancing Estrogen-Progesterone Signals and Promoting Decidual Angiogenesis Through FGF2 During Early Pregnancy.
Bushen Huoxue Recipe Alleviates Implantation Loss in Mice by Enhancing Estrogen-Progesterone Signals and Promoting Decidual Angiogenesis Through FGF2 During Early Pregnancy.
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补肾活血方通过在妊娠早期增强雌激素-孕激素信号并通过 FGF2 促进蜕膜血管生成来减轻小鼠着床失败
DOI：
10.3389/fphar.2018.00437
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发表时间：
2018
影响因子：
5.6
通讯作者：
Zhang M
中科院分区：
文献类型：
--
作者：
Ding J;Tan X;Song K;Ma W;Xiao J;Song Y;Zhang M
补肾活血方（BSHXR）是一种具有补肾活血功效的经典中药方剂。由黄芪、当归、川芎、菟丝子、红豆杉、白头翁六种中药组成，其主要有效成分为阿魏酸、毛蕊花苷-7-葡萄糖苷、金丝桃苷、槲皮苷、曲霉皂苷VI。在临床中，传统上用于治疗妊娠失败及其并发症。然而，BSHXR治疗妊娠早期着床丢失的潜在机制尚不清楚。在本研究中，我们以小鼠为着床丢失模型，诱导控制性卵巢过度刺激，并评估BSHXR对着床、蜕膜、蜕膜血管生成和生殖结局的影响。我们发现BSHXR可以调节小鼠血清雌激素和孕酮的生理水平，并对间质和上皮内的雌激素和孕酮受体起作用。BSHXR还能增强蜕膜血管窦折叠区FGF2的表达，从而潜在地减少妊娠早期的着床损失，有助于胎儿的胎盘和存活。综上所述，我们的研究结果为BSHXR作为早期妊娠着床丢失的治疗在临床上的应用提供了科学依据，值得进一步研究BSHXR作为失败妊娠及其并发症的有效治疗。
Bushen Huoxue recipe (BSHXR) is a classic Chinese herbal prescription for nourishing the kidney and activating blood circulation. It consists of six herbs: Astragali radix, Angelicae sinensis radix, Ligustici Chuanxiong Rhizoma, Cuscutae semen, Taxilli Herba, and Dipsaci Radix, and the main active constituents of BSHXR are ferulic acid, calycosin-7-glucopyranoside, hyperoside, quercitrin, and asperosaponin VI. In clinical practice, BSHXR is traditionally used to treat failed pregnancy and its complications. However, little is known about the underlying mechanism of BSHXR for the treatment of implantation loss during early pregnancy. In the current study, controlled ovarian hyperstimulation was induced in mice as our implantation loss model, and we evaluated the effects of BSHXR on implantation, decidualization, decidual angiogenesis, and reproductive outcome. We showed that BSHXR could regulate the supraphysiological levels of serum estrogen and progesterone observed in these mice, and also act on estrogen and progesterone receptors in the stroma and epithelium. BSHXR also enhanced FGF2 expression in the vascular sinus folding area of the decidua, thus potentially reducing implantation loss during early pregnancy and contributing to placentation and survival of the fetuses. Taken together, our findings provide scientific evidence for the application of BSHXR in the clinic as a treatment for implantation loss during early pregnancy, and warrant further investigation of BSHXR as an effective treatment for failed pregnancy and its complications.
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影响因子：
82.9
作者：
Cha J;Sun X;Dey SK
通讯作者：
Dey SK
DOI：
10.1111/j.0001-6349.2004.00256.x
发表时间：
2004-02-01
影响因子：
4.3
作者：
Matsui, N;Kawano, Y;Miyakawa, I
通讯作者：
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影响因子：
2
作者：
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通讯作者：
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影响因子：
2.7
作者：
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通讯作者：
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