Toward a control theory analysis of aging.
Toward a control theory analysis of aging.
复制标题
DOI：
10.1146/annurev.biochem.77.070606.101605
复制
发表时间：
2008
影响因子：
16.6
通讯作者：
Partridge L
中科院分区：
文献类型：
--
作者：
Murphy MP;Partridge L
衰老是由于随着时间的推移，损害的积累影响了有机体的功能和生存；然而，事实证明很难推断出许多导致衰老的过程的相对重要性。为了解决这个问题，我们在这里概述了一种可能在分析衰老方面有用的方法。在这种方法中，生物体的功能被描述为一组相互作用的生理系统。它们的输出退化会导致功能衰退和衰老导致的死亡。反过来，系统输出的退化可归因于下一个层级（即细胞）通过细胞数量或功能的变化而发生的变化，而这又是细胞代谢历史的结果。在此框架内，我们随后采用代谢控制分析（MCA）方法来确定哪些修饰对衰老很重要。这种分层框架和 MCA 方法的结合可能对于思考衰老和实验分析都很有用。
Aging is due to the accumulation of damage over time that affects the function and survival of the organism; however, it has proven difficult to infer the relative importance of the many processes that contribute to aging. To address this, here we outline an approach that may prove useful in analyzing aging. In this approach, the function of the organism is described as a set of interacting physiological systems. Degradation of their outputs leads to functional decline and death as a result of aging. In turn, degradation of the system outputs is attributable to changes at the next hierarchical level down, the cell, through changes in cell number or function, which are in turn a consequence of the metabolic history of the cell. Within this framework, we then adapt the methods of metabolic control analysis (MCA) to determine which modifications are important for aging. This combination of a hierarchical framework and the methodologies of MCA may prove useful both for thinking about aging and for analyzing it experimentally.
登录
查看更多内容
DOI：
10.1093/gerona/62.4.352
发表时间：
2007-04-01
影响因子：
5.1
作者：
Ayala, Victoria;Naudi, Alba;Pamplona, Reinald
通讯作者：
Pamplona, Reinald
影响因子：
64.8
作者：
Conboy, IM;Conboy, MJ;Rando, TA
通讯作者：
Rando, TA
影响因子：
56.9
作者：
Clancy, DJ;Gems, D;Partridge, L
通讯作者：
Partridge, L
影响因子：
4.3
作者：
Boehm, Michelle;Slack, Frank J.
通讯作者：
Slack, Frank J.
影响因子：
3.5
作者：
Aoshiba, Kazutetsu;Nagai, Atsushi
通讯作者：
Nagai, Atsushi