Altered small-world brain networks in schizophrenia patients during working memory performance.
Altered small-world brain networks in schizophrenia patients during working memory performance.
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DOI：
10.1371/journal.pone.0038195
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发表时间：
2012
期刊：
影响因子：
3.7
通讯作者：
Calhoun VD
中科院分区：
文献类型：
--
作者：
He H;Sui J;Yu Q;Turner JA;Ho BC;Sponheim SR;Manoach DS;Clark VP;Calhoun VD
精神分裂症患者(SZ)的工作记忆(WM)表现受损是公认的。与健康对照组(HC)相比，SZ患者在WM执行过程中表现出异常的血氧水平依赖(BOLD)激活和功能连接中断。在这项研究中，我们考察了35个HC和35个SZ在三个WM负荷水平下执行Sternberg项目识别范式(SIRP)时收集的功能磁共振成像(FMRI)数据计算的小世界网络指标。通过计算任务相关脑感兴趣区(ROI)与组独立成分分析(ICA)定义的任务相关脑感兴趣区(ROI)之间BOLD信号的预处理时间进程的偏相关来构建功能连接网络。然后在小世界机制内对这些网络设置阈值，从而在不同的工作内存负载下产生无向二值化的小世界网络。研究结果表明：1)在中等工作管理负荷水平下，深圳的网络表现出较低的聚集系数和较低的局部效率；2)在深圳，随着工作管理负荷水平从低到中、从中到高，大多数网络度量发生显著变化，而在不同工作管理负荷水平下，高工作管理网络的网络度量相对稳定；3)在中等工作管理负荷下，深圳的网络结构变化与其在任务中的表现有关，反应时较长，与较低的聚集系数和较低的局部效率有关。这些发现表明，与HC相比，SZ患者的大脑连接在西医中间水平的功能网络中更分散，局部联系不那么强烈。与HC中稳定的高分簇网络结构相比，SZ在WM负载增加时表现出明显的低效和可变的网络结构。
Impairment of working memory (WM) performance in schizophrenia patients (SZ) is well-established. Compared to healthy controls (HC), SZ patients show aberrant blood oxygen level dependent (BOLD) activations and disrupted functional connectivity during WM performance. In this study, we examined the small-world network metrics computed from functional magnetic resonance imaging (fMRI) data collected as 35 HC and 35 SZ performed a Sternberg Item Recognition Paradigm (SIRP) at three WM load levels. Functional connectivity networks were built by calculating the partial correlation on preprocessed time courses of BOLD signal between task-related brain regions of interest (ROIs) defined by group independent component analysis (ICA). The networks were then thresholded within the small-world regime, resulting in undirected binarized small-world networks at different working memory loads. Our results showed: 1) at the medium WM load level, the networks in SZ showed a lower clustering coefficient and less local efficiency compared with HC; 2) in SZ, most network measures altered significantly as the WM load level increased from low to medium and from medium to high, while the network metrics were relatively stable in HC at different WM loads; and 3) the altered structure at medium WM load in SZ was related to their performance during the task, with longer reaction time related to lower clustering coefficient and lower local efficiency. These findings suggest brain connectivity in patients with SZ was more diffuse and less strongly linked locally in functional network at intermediate level of WM when compared to HC. SZ show distinctly inefficient and variable network structures in response to WM load increase, comparing to stable highly clustered network topologies in HC.
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影响因子：
4.3
作者：
Achard S;Bullmore E
通讯作者：
Bullmore E
在认知控制性能过程中，第一期精神分裂症中的一般和特定的功能连通性干扰。
影响因子：
10.6
作者：
Fornito, Alex;Yoon, Jong;Zalesky, Andrew;Bullmore, Edward T.;Carter, Cameron S.
通讯作者：
Carter, Cameron S.
影响因子：
5.3
作者：
Achard, S;Salvador, R;Bullmore, ET
通讯作者：
Bullmore, ET
DOI：
10.1073/pnas.0504136102
发表时间：
2005-07-05
影响因子：
11.1
作者：
Fox, MD;Snyder, AZ;Raichle, ME
通讯作者：
Raichle, ME
影响因子：
17.7
作者：
Callicott, JH;Mattay, VS;Weinberger, DR
通讯作者：
Weinberger, DR