Liposomal formulation of amphiphilic fullerene antioxidants.
Liposomal formulation of amphiphilic fullerene antioxidants.
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DOI：
10.1021/bc1001664
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发表时间：
2010-09-15
影响因子：
4.7
通讯作者：
Kepley, Christopher L.
中科院分区：
文献类型：
--
作者：
Zhou, Zhiguo;Lenk, Robert P.;Dellinger, Anthony;Wilson, Stephen R.;Sadler, Robert;Kepley, Christopher L.
据报道，新型两亲性富勒烯[70]衍生物经过合理设计可嵌入脂质双层，其囊泡制剂具有高达65%重量的令人惊讶的高负载能力。浮力密度测试、粒径分布和 31P NMR 证明，两亲性 C70 双加合物与辅助天然磷脂形成均匀且尺寸稳定的脂质体。电子顺磁共振 (EPR) 研究和体外活性氧 (ROS) 抑制实验表明，双极性功能化 C70 衍生物、两亲性脂质体丙二酰富勒烯 [70] (ALM) 及其脂质体制剂中保留了富勒烯的抗氧化特性。脂质体配制的 ALM 可有效猝灭羟基自由基和超氧自由基。此外，富勒烯脂质体抑制自由基诱导的脂质过氧化并保持脂质双层结构的完整性。这种新型脂质体配制的两亲性富勒烯化合物代表了一种新型的富勒烯药物递送系统，并为治疗氧化应激相关疾病提供了一条有前途的途径。
Novel amphiphilic fullerene[70] derivatives that are rationally designed to intercalate in lipid bilayers are reported, as well as its vesicular formulation with surprisingly high loading capacity up to 65% by weight. The amphiphilic C70 bisadduct forms uniform and dimensionally stable liposomes with auxiliary natural phospholipids as demonstrated by buoyant density test, particle size distribution and 31P NMR. The antioxidant property of fullerenes is retained in the bipolarly functionalized C70 derivative, Amphiphilic Liposomal Malonylfullerene[70] (ALM) as well as in its liposomal formulations, as shown by both electron paramagnetic resonance (EPR) studies and in vitro reactive oxygen species (ROS) inhibition experiments. The liposomally formulated ALM efficiently quenched hydroxyl radicals and superoxide radicals. In addition, the fullerene liposome inhibited radical-induced lipid peroxidation and maintained the integrity of the lipid bilayer structure. This new class of liposomally formulated, amphipathic fullerene compounds represents a novel drug delivery system for fullerenes and provides a promising pathway to treat oxidative stress-related diseases.
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影响因子：
1.8
作者：
Brettreich, M;Hirsch, A
通讯作者：
Hirsch, A
影响因子：
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作者：
Lens, Marko;Medenica, Ljiljana;Citernesi, Ugo
通讯作者：
Citernesi, Ugo
影响因子：
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作者：
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通讯作者：
OSTRO, MJ
影响因子：
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作者：
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通讯作者：
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影响因子：
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作者：
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通讯作者：
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