Association of interleukin-6 gene promoter polymorphism with coronary artery disease in Pakistani families.
Association of interleukin-6 gene promoter polymorphism with coronary artery disease in Pakistani families.
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DOI：
10.1155/2013/538365
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发表时间：
2013
影响因子：
--
通讯作者：
Javed Q
中科院分区：
文献类型：
--
作者：
Satti HS;Hussain S;Javed Q
白细胞介素-6（IL-6）是一种众所周知的炎症细胞因子，被认为与冠状动脉疾病（CAD）的发生发展有关。IL-6基因在CAD患者中的表达研究存在争议。本研究调查了IL-6基因表达与CAD的关联，这是巴基斯坦人群中白细胞介素-6表达调节的分子基础。我们的数据显示，与健康对照组相比，冠心病患者血清IL-6水平升高，IL-6基因-174位点多态性在冠心病患者中更常见。IL-6基因多态性与CAD之间存在统计学显著相关性，这可能与疾病风险增加有关。CC基因型患者外周血IL-6和hs-CRP水平显著高于CC基因型患者（P < 0.0001和P < 0.0001）。在二元逻辑回归模型中，发现CAD与血清IL-6和hs-CRP水平升高以及-174G>C多态性之间存在独立关联。这是第一份关于巴基斯坦CAD患者IL-6表达和IL-6基因多态性的报告，因此它突出了该疾病的一个新的危险因素。
Interleukin-6 (IL-6) is a well-known inflammatory cytokine and suggested to be involved in the development of coronary artery disease (CAD). IL-6 gene expression has been investigated with controversy in CAD patients. This study investigates the association of the IL-6 gene expression with CAD, the molecular basis for the regulation of interleukin-6 expression in a Pakistani population. Our data show that the serum IL-6 levels were increased in patients with CAD compared with healthy controls and that the IL-6 gene polymorphism at -174 was more prevalent in CAD cases. There was a statistically significant association between the IL-6 gene polymorphism and CAD, which may be associated with an increased risk for the disease. Moreover, circulating IL-6 and hs-CRP levels were significantly higher in patients with CC genotype (P < 0.0001 and P < 0.0001, resp.). In a binary logistic-regression model, an independent association was found between CAD and increased serum IL-6 and hs-CRP levels and -174G>C polymorphism. This is the first report on the IL-6 expression and the IL-6 gene polymorphism in patients with CAD from Pakistan, and hence it highlights a novel risk factor for the disease.
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