The influence of light on temperature preference in Drosophila.
The influence of light on temperature preference in Drosophila.
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DOI：
10.1016/j.cub.2015.02.038
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发表时间：
2015-04-20
期刊：
影响因子：
9.2
通讯作者：
Hamada, Fumika N.
中科院分区：
文献类型：
--
作者：
Head, Lauren M.;Tang, Xin;Hayley, Sean E.;Goda, Tadahiro;Umezaki, Yujiro;Chang, Elaine C.;Leslie, Jennifer R.;Fujiwara, Mana;Garrity, Paul A.;Hamada, Fumika N.
环境光影响多种生理功能和行为，如昼夜节律，睡眠-觉醒活动，以及从苍蝇到哺乳动物的发育。哺乳动物在暴露于强光下时比暴露于黑暗中时表现出更高的体温，但其潜在机制在很大程度上尚不清楚。果蝇等小型生态恒温动物的体温依赖于周围环境的温度，这些动物表现出强烈的温度偏好行为。在这里，我们证明了果蝇更喜欢一个温度高一度时，暴露在急性光，而不是黑暗。这种急性光反应，光依赖性温度偏好（LDTP），无论一天中的时间，这表明LDTP是从生物钟单独调节。然而，眼和昼夜节律钟突变体的筛选表明，昼夜节律钟神经元，后背神经元1（DN 1 ps）和色素分散因子受体（pdfr）在LDTP中发挥作用。为了进一步研究DN 1 ps在LDTP中的作用，DN 1 ps中的pdfr被敲低，导致异常LDTP。PDFR突变体的表型通过在DN 1 ps中表达PDFR而得到充分拯救，表明DN 1 ps中的PDFR表达是LDTP的原因。这些结果表明，光通过昼夜节律钟神经元DN 1 ps积极影响温度偏好，这可能是由于光和温度信息的整合。鉴于果蝇和哺乳动物都通过增加体温来对急性光做出反应，急性光对温度调节的影响可能在果蝇和人类之间进化上是保守的。
Ambient light affects multiple physiological functions and behaviors, such as circadian rhythms, sleep-wake activities, and development from flies to mammals. Mammals exhibit a higher body temperature when exposed to acute light compared to when they are exposed to dark, but the underlying mechanisms are largely unknown. The body temperature of small ecotherms, such as Drosophila, rely on the temperature of their surrounding environment and these animals exhibit a robust temperature preference behavior. Here, we demonstrate that Drosophila prefer a one-degree higher temperature when exposed to acute light rather than dark. This acute light response, light dependent temperature preference (LDTP), was observed regardless of the time of day, suggesting that LDTP is regulated separately from the circadian clock. However, screening of eye and circadian clock mutants suggests that the circadian clock neurons, posterior dorsal neurons 1 (DN1ps) and pigment-dispersing factor receptor (pdfr) play a role in LDTP. To further investigate the role of DN1ps in LDTP, pdfr in DN1ps was knocked down, resulting in an abnormal LDTP. The phenotype of the pdfr mutant was sufficiently rescued by expressing pdfr in DN1ps, indicating that pdfr expression in DN1ps is responsible for LDTP. These results suggest that light positively influences temperature preference via the circadian clock neurons, DN1ps, which may result from the integration of light and temperature information. Given that both Drosophila and mammals respond to acute light by increasing their body temperature, the effect of acute light on temperature regulation may be conserved evolutionarily between flies and humans.
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影响因子：
2.5
作者：
Helfrich-Förster, C
通讯作者：
Helfrich-Förster, C
影响因子：
64.8
作者：
Hong, Sung-Tae;Bang, Sunhoe;Kim, Jaeseob
通讯作者：
Kim, Jaeseob
影响因子：
64.8
作者：
Grima, B;Chèlot, E;Rouyer, F
通讯作者：
Rouyer, F
DOI：
10.1007/s12052-008-0086-z
发表时间：
2008-10-01
期刊：
Evolution Education and Outreach
影响因子：
--
作者：
Buschbeck, Elke K.;Friedrich, Markus
通讯作者：
Friedrich, Markus
影响因子：
3.7
作者：
Im SH;Li W;Taghert PH
通讯作者：
Taghert PH