A comparative study on the neurophysiological mechanisms underlying effects of methylphenidate and neurofeedback on inhibitory control in attention deficit hyperactivity disorder.
A comparative study on the neurophysiological mechanisms underlying effects of methylphenidate and neurofeedback on inhibitory control in attention deficit hyperactivity disorder.
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DOI：
10.1016/j.nicl.2018.10.027
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发表时间：
2018
期刊：
影响因子：
--
通讯作者：
Beste C
中科院分区：
文献类型：
--
作者：
Bluschke A;Friedrich J;Schreiter ML;Roessner V;Beste C
对于注意力缺陷多动障碍 (AD(H)D)，使用哌醋甲酯 (MPH) 的治疗和神经反馈 (NF) 等行为干预措施反映了主要的治疗选择。这些治疗还可以改善 AD(H)D 的执行功能障碍。然而，MPH 和 NF 对 AD(H)D 执行功能（例如抑制强效反应的能力）的潜在影响机制尚不清楚。目前还不清楚这些干预措施是否影响相似或可分离的神经机制以及相关的功能性神经解剖结构。然而，当旨在进一步改进这些治疗方法时，这一点很重要。我们根据脑电图记录和源定位分析比较了 MPH 和 theta/beta NF 治疗对抑制控制的神经生理学机制。数据显示 MPH 和 theta/beta NF 都以相似的程度增加抑制预效反应的能力。然而，数据表明 MPH 和 NF 针对不同的神经生理机制，特别是当涉及到与这些效应相关的功能性神经解剖结构时。这两种治疗似乎都会影响内侧额叶区域“制动功能”的神经生理学相关性。然而，在 NF 干预的情况下，下顶叶区域也会受到影响。这可能反映了有效的内部代表的更新和稳定，以便采取适当的行动。在知觉和注意力选择过程的相关性中没有发现任何影响。值得注意的是，只有在考虑了神经生理学数据的个体内变异性后才能获得可靠的效果，这也可以解释 AD(H)D 治疗效果研究结果的多样性，特别是在神经反馈方面。比较了哌醋甲酯 (MPH) 和神经反馈 (NF) 在 ADHD 中的神经生理机制。两种治疗方法都可以改善抑制作用，但具有不同的潜在神经生理机制。两种治疗都会影响内侧额叶区域“破坏功能”的神经生理学相关性。神经纤维瘤还影响下顶叶区域，并可能影响内部表征的更新。只有在考虑个体内部差异时才能看到独特的效果。
In Attention Deficit Hyperactivity Disorder (AD(H)D), treatments using methylphenidate (MPH) and behavioral interventions like neurofeedback (NF) reflect major therapeutic options. These treatments also ameliorate executive dysfunctions in AD(H)D. However, the mechanisms underlying effects of MPH and NF on executive functions in AD(H)D (e.g. the ability to inhibit prepotent responses) are far from understood. It is particularly unclear whether these interventions affect similar or dissociable neural mechanisms and associated functional neuroanatomical structures. This, however, is important when aiming to further improve these treatments. We compared the neurophysiological mechanisms of MPH and theta/beta NF treatments on inhibitory control on the basis of EEG recordings and source localization analyses. The data show that MPH and theta/beta NF both increase the ability to inhibit pre-potent responses to a similar extent. However, the data suggest that MPH and NF target different neurophysiological mechanisms, especially when it comes to functional neuroanatomical structures associated with these effects. Both treatments seem to affect neurophysiological correlates of a ‘braking function’ in medial frontal areas. However, in case of the NF intervention, inferior parietal areas are also involved. This likely reflects the updating and stabilisation of efficient internal representations in order to initiate appropriate actions. No effects were seen in correlates of perceptual and attentional selection processes. Notably, reliable effects were only obtained after accounting for intra-individual variability in the neurophysiological data, which may also explain the diversity of findings in studies on treatment effects in AD(H)D, especially concerning neurofeedback. Neurophysiological mechanisms of methylphenidate (MPH) and neurofeedback (NF) in ADHD are compared. Both treatments improve inhibition, but have different underlying neurophysiological mechanisms. Both treatments affect the neurophysiological correlates of a ‘breaking function’ in medial frontal areas. NF also affects inferior parietal areas and likely the updating of internal representations. Distinctive effects are only seen when accounting for intra-individual variability.
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影响因子：
4.8
作者：
Chmielewski, Witold X.;Mueckschel, Moritz;Beste, Christian
通讯作者：
Beste, Christian
影响因子：
5.7
作者：
Bianco, V.;Berchicci, M.;Di Russo, F.
通讯作者：
Di Russo, F.
影响因子：
2
作者：
Arns, Martijn;de Ridder, Sabine;Coenen, Anton
通讯作者：
Coenen, Anton
影响因子：
4.6
作者：
Bluschke A;Broschwitz F;Kohl S;Roessner V;Beste C
通讯作者：
Beste C
DOI：
10.1080/13803390490515757
发表时间：
2005-04-01
影响因子：
2.2
作者：
Boonstra, AM;Kooij, JSS;Buitelaar, JK
通讯作者：
Buitelaar, JK