Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
Organization of neural systems expressing melanocortin-3 receptors in the mouse brain: Evidence for sexual dimorphism.
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在小鼠大脑中表达黑素皮质3受体的神经系统的组织：性二态性的证据。
DOI：
10.1002/cne.25379
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发表时间：
2022-11
影响因子：
2.5
通讯作者：
Simerly, Richard B.
中科院分区：
文献类型：
--
作者：
Bedenbaugh, Michelle N.;Brener, Samantha C.;Maldonado, Jose;Lippert, Rachel N.;Sweeney, Patrick;Cone, Roger D.;Simerly, Richard B.
中枢黑皮质素系统对于控制食物摄入和能量稳态至关重要。黑皮质素-3受体（MC 3R）是在大脑中发现的黑皮质素系统的两种主要受体之一。与特征良好的黑皮质素-4受体（MC 4 R）相反，关于MC 3R表达神经回路的组织知之甚少。为了增加我们对MC 3R神经回路内在组织的理解，识别男性和女性之间的特定差异，并获得该回路的神经系统水平视角，我们对标记为MC 3R的神经元进行了全脑映射，并表征了其投射的分布。分析显示，MC 3R神经元和终端标签在多个大脑区域，控制各种各样的生理功能和行为过程。值得注意的是，在下丘脑以及与下丘脑有相当大联系的区域（包括皮质、杏仁核、丘脑和脑干）中观察到密集标记。此外，MC 3R神经元标记在几个领域，包括前腹侧脑室周围区，弓状核，终纹床核的主核，和腹侧乳头体前区的性二态性。总而言之，这里报告的解剖学证据表明，MC 3R有可能影响几种不同类别的动机行为，这些行为对生存至关重要，包括摄食，生殖，防御和唤醒行为，并且可能在男性和女性中不同地调节这些行为。
The central melanocortin system is fundamentally important for controlling food intake and energy homeostasis. Melanocortin-3 receptor (MC3R) is one of two major receptors of the melanocortin system found in the brain. In contrast to the well-characterized melanocortin-4 receptor (MC4R), little is known regarding the organization of MC3R-expressing neural circuits. To increase our understanding of the intrinsic organization of MC3R neural circuits, identify specific differences between males and females, and gain a neural systems level perspective of this circuitry, we conducted a brain-wide mapping of neurons labeled for MC3R and characterized the distribution of their projections. Analysis revealed MC3R neuronal and terminal labeling in multiple brain regions that control a diverse range of physiological functions and behavioral processes. Notably, dense labeling was observed in the hypothalamus, as well as areas that share considerable connections with the hypothalamus, including the cortex, amygdala, thalamus, and brainstem. Additionally, MC3R neuronal labeling was sexually dimorphic in several areas, including the anteroventral periventricular area, arcuate nucleus, principal nucleus of the bed nucleus of the stria terminalis, and ventral premammillary region. Altogether, anatomical evidence reported here suggests that MC3R has the potential to influence several different classes of motivated behavior that are essential for survival, including ingestive, reproductive, defensive, and arousal behaviors, and is likely to modulate these behaviors differently in males and females.
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影响因子：
9.8
作者：
Chandramohan, Gangadarshni;Durham, Nicquanna;Vaziri, Nosratola D.
通讯作者：
Vaziri, Nosratola D.
影响因子：
16.2
作者：
Burnett CJ;Li C;Webber E;Tsaousidou E;Xue SY;Brüning JC;Krashes MJ
通讯作者：
Krashes MJ
影响因子：
3.4
作者：
Dean, Kevin M.;Roudot, Philippe;Welf, Erik S.;Danuser, Gaudenz;Fiolka, Reto
通讯作者：
Fiolka, Reto
影响因子：
4.8
作者：
Begriche, Karima;Levasseur, Peter R.;Butler, Andrew A.
通讯作者：
Butler, Andrew A.
DOI：
10.1002/oby.22306
发表时间：
2018-12
期刊：
Obesity (Silver Spring, Md.)
影响因子：
--
作者：
Girardet C;Marks DL;Butler AA
通讯作者：
Butler AA