Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease.
Self-rated and informant-rated everyday function in comparison to objective markers of Alzheimer's disease.
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DOI：
10.1016/j.jalz.2014.09.002
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发表时间：
2015-09
影响因子：
14
通讯作者：
Farias, Sarah Tomaszewski
中科院分区：
文献类型：
--
作者：
Rueda, Alicia D.;Lau, Karen M.;Saito, Naomi;Harvey, Danielle;Risacher, Shannon L.;Aisen, Paul S.;Petersen, Ronald C.;Saykin, Andrew J.;Farias, Sarah Tomaszewski
关键词：
人们认识到，患有轻度认知障碍（MCI）的个体在日常功能方面已经表现出困难，这预示着疾病的进展。本研究考察了自我报告与举报人报告的功能能力之间的关系，以及这些报告如何与整个疾病谱系（即认知正常、轻度认知障碍、阿尔茨海默病）的客观疾病测量相关联。共有1080名受试者接受了自我和/或被告知的日常认知（ECog）问卷调查。客观测量包括认知功能、结构性脑萎缩、脑脊液（CSF）异常，以及使用[18F]AV45 （florbetapir）使用正电子发射断层扫描（PET）检测淀粉样蛋白沉积标志物。总体而言，尽管自我报告的功能状态可能在早期疾病中仍有一些效用，但举报人报告始终比自我报告与疾病的客观标记更相关。
It is recognized that individuals with mild cognitive impairment (MCI) already demonstrate difficulty in aspects of daily functioning, which predicts disease progression. This study examined the relationship between self- versus informant-report of functional ability, and how those reports relate to objective disease measures across the disease spectrum (i.e. cognitively normal, MCI, Alzheimer’s disease). A total of 1,080 subjects with self- and/or informant-rated Everyday Cognition (ECog) questionnaires were included. Objective measures included cognitive functioning, structural brain atrophy, cerebrospinal fluid (CSF) abnormalities, and a marker of amyloid deposition using positron emission tomography (PET) with [18F]AV45 (florbetapir). Overall, informant-report was consistently more associated with objective markers of disease than self-report although self-reported functional status may still have some utility in early disease.
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影响因子：
2.4
作者：
Hohman TJ;Beason-Held LL;Lamar M;Resnick SM
通讯作者：
Resnick SM
影响因子：
5.7
作者：
Fischl, B;Sereno, MI;Dale, AM
通讯作者：
Dale, AM
影响因子：
2.6
作者：
Amariglio RE;Becker JA;Carmasin J;Wadsworth LP;Lorius N;Sullivan C;Maye JE;Gidicsin C;Pepin LC;Sperling RA;Johnson KA;Rentz DM
通讯作者：
Rentz DM
DOI：
10.1080/01688639008400980
发表时间：
1990-03-01
影响因子：
2.2
作者：
DEBETTIGNIES, BH;MAHURIN, RK;PIROZZOLO, FJ
通讯作者：
PIROZZOLO, FJ
影响因子：
3.7
作者：
Farias, Sarah Tomaszewski;Chou, Elizabeth;Beckett, Laurel
通讯作者：
Beckett, Laurel