The role of obesity and bariatric surgery-induced weight loss in breast cancer.
The role of obesity and bariatric surgery-induced weight loss in breast cancer.
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DOI：
10.1007/s10555-022-10050-6
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发表时间：
2022-09
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影响因子：
--
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中科院分区：
文献类型：
--
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肥胖是一种复杂的代谢疾病，被认为是全球性的公共卫生危机，迫切需要对肥胖相关疾病的机制有更深入的了解。肥胖合并症包括许多相关的癌症，估计占美国女性癌症死亡的20%。特别是乳腺癌，与肥胖有关，是这次审查的重点。肥胖和乳腺癌之间的确切因果关系尚不清楚。尽管如此，体重指数，肿瘤分子亚型，遗传背景和环境因素之间的相互作用已经出现，强烈表明肥胖影响某些乳腺癌的风险和进展。支持性临床前研究使用各种饮食诱导的肥胖模型来证明，通过饮食干预或能量消耗的变化来减轻体重，可以减少乳腺癌的发生或进展。目前正在进行和未来的研究旨在阐明减肥驱动观察背后的基础机制，以改善乳腺癌患者的治疗和结局并降低风险。本综述旨在总结肥胖和减肥策略的快速新兴文献，重点讨论临床和临床前研究中的减肥手术，详细说明肥胖和乳腺癌背景下代谢，免疫反应和免疫治疗之间的复杂相互作用。
Obesity is a complex metabolic condition considered a worldwide public health crisis, and a deeper mechanistic understanding of obesity-associated diseases is urgently needed. Obesity comorbidities include many associated cancers and are estimated to account for 20% of female cancer deaths in the USA. Breast cancer, in particular, is associated with obesity and is the focus of this review. The exact causal links between obesity and breast cancer remain unclear. Still, interactions have emerged between body mass index, tumor molecular subtype, genetic background, and environmental factors that strongly suggest obesity influences the risk and progression of certain breast cancers. Supportive preclinical research uses various diet-induced obesity models to demonstrate that weight loss, via dietary interventions or changes in energy expenditure, reduces the onset or progression of breast cancers. Ongoing and future studies are now aimed at elucidating the underpinning mechanisms behind weight-loss-driven observations to improve therapy and outcomes in patients with breast cancer and reduce risk. This review aims to summarize the rapidly emerging literature on obesity and weight loss strategies with a focused discussion of bariatric surgery in both clinical and preclinical studies detailing the complex interactions between metabolism, immune response, and immunotherapy in the setting of obesity and breast cancer.
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影响因子：
2.9
作者：
Chambers, Adam P.;Stefater, Margaret A.;Wilson-Perez, Hilary E.;Jessen, Lene;Sisley, Stephanie;Ryan, Karen K.;Gaitonde, Shrawan;Sorrell, Joyce E.;Toure, Mouhamadoul;Berger, Jose;D'Alessio, David A.;Sandoval, Darleen A.;Seeley, Randy J.;Woods, Stephen C.
通讯作者：
Woods, Stephen C.
影响因子：
3.7
作者：
Gillespie EF;Sorbero ME;Hanauer DA;Sabel MS;Herrmann EJ;Weiser LJ;Jagielski CH;Griggs JJ
通讯作者：
Griggs JJ
影响因子：
50.5
作者：
Ali, H. R.;Glont, S. -E.;Caldas, C.
通讯作者：
Caldas, C.
影响因子：
3.7
作者：
Agabiti-Rosei C;Trapletti V;Piantoni S;Airò P;Tincani A;De Ciuceis C;Rossini C;Mittempergher F;Titi A;Portolani N;Caletti S;Coschignano MA;Porteri E;Tiberio GAM;Pileri P;Solaini L;Kumar R;Ministrini S;Agabiti Rosei E;Rizzoni D
通讯作者：
Rizzoni D
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影响因子：
30.5
作者：
Beatson R;Tajadura-Ortega V;Achkova D;Picco G;Tsourouktsoglou TD;Klausing S;Hillier M;Maher J;Noll T;Crocker PR;Taylor-Papadimitriou J;Burchell JM
通讯作者：
Burchell JM