Startle Habituation and Midfrontal Theta Activity in Parkinson Disease.
Startle Habituation and Midfrontal Theta Activity in Parkinson Disease.
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DOI：
10.1162/jocn_a_01012
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发表时间：
2016-12
影响因子：
3.2
通讯作者：
Narayanan NS
中科院分区：
文献类型：
--
作者：
Chen KH;Okerstrom KL;Kingyon JR;Anderson SW;Cavanagh JF;Narayanan NS
适应厌恶刺激的能力对心理健康至关重要。在这里，我们调查的习惯，以惊人的刺激和惊吓相关的活动，在内侧额叶皮层脑电图测量健康对照组和帕金森病（PD）患者之间的关系。我们报告三个发现。首先，PD患者表现出正常的初始惊吓反应，但减少惊吓习惯相对于人口统计学匹配的对照。第二，对照组受试者对惊人的刺激有中额叶脑电θ波活动，而PD患者的这种活动减弱。最后，与惊吓相关的中额叶theta活动与惊吓习惯化率相关。这些数据表明，受损的惊吓习惯性PD是一个衰减的中额叶认知控制信号的结果。我们的研究结果可以提供深入了解惊吓习惯化的额叶调节。
The ability to adapt to aversive stimuli is critical for mental health. Here, we investigate the relationship between habituation to startling stimuli and startle-related activity in medial frontal cortex as measured by EEG in both healthy control participants and patients with Parkinson disease (PD). We report three findings. First, patients with PD exhibited normal initial startle responses but reduced startle habituation relative to demographically matched controls. Second, control participants had midfrontal EEG theta activity in response to startling stimuli, and this activity was attenuated in patients with PD. Finally, startle-related midfrontal theta activity was correlated with the rate of startle habituation. These data indicate that impaired startle habituation in PD is a result of attenuated midfrontal cognitive control signals. Our findings could provide insight into the frontal regulation of startle habituation.
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影响因子：
16.2
作者：
Fries P
通讯作者：
Fries P
影响因子：
10.6
作者：
Cools, Roshan;D'Esposito, Mark
通讯作者：
D'Esposito, Mark
DOI：
10.1080/01688639108405107
发表时间：
1991-11-01
影响因子：
2.2
作者：
ANDERSON, SW;DAMASIO, H;TRANEL, D
通讯作者：
TRANEL, D
影响因子：
3.3
作者：
Ellenbroek, BA;Budde, S;Cools, AR
通讯作者：
Cools, AR
影响因子：
3.4
作者：
BUBSER, M;KOCH, M
通讯作者：
KOCH, M