First trimester uric acid and adverse pregnancy outcomes.
First trimester uric acid and adverse pregnancy outcomes.
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DOI：
10.1038/ajh.2010.262
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发表时间：
2011-04
影响因子：
3.2
通讯作者：
Gandley, Robin E.
中科院分区：
文献类型：
--
作者：
Laughon, S. Katherine;Catov, Janet;Powers, Robert W.;Roberts, James M.;Gandley, Robin E.
血清尿酸升高与高血压的发生之间的关系在妊娠期外就已确立。我们调查了妊娠早期尿酸是否与以下疾病的发生相关：妊娠期高血压或先兆子痫，这些结局根据分娩时是否存在高尿酸血症分层，因为这意味着更严重的疾病、早产或小于胎龄儿（SGA）。从先前的前瞻性队列研究中收集的1541份母亲血浆样本中测量尿酸，这些样本在平均孕龄9.0（± 2.5）周时收集。进行多分割回归分析，并根据产次和孕前体重指数进行调整。与最低三个四分位数相比，妊娠早期尿酸最高四分位数（>3.56 mg/dL）与先兆子痫风险增加相关（校正OR = 1.82; 95%CI，1.03-3.21），但与妊娠期高血压无关。在分娩时合并高尿酸血症的高血压患者中，妊娠早期高尿酸血症与高尿酸血症性妊娠高血压风险增加3.22倍和高尿酸血症性先兆子痫风险增加3.65倍相关。妊娠早期高尿酸与分娩时无高尿酸血症的妊娠期高血压或先兆子痫、早产或SGA无关。在患有高血压疾病的女性中，分娩时尿酸升高仅部分由妊娠早期尿酸升高解释（r2 = 0.23）。妊娠早期尿酸升高与晚期先兆子痫相关，与先兆子痫和妊娠期高血压伴高尿酸血症相关性更强。
The association of elevated serum uric acid with the development of hypertension is established outside of pregnancy. We investigated whether first trimester uric acid was associated with the development of the following: gestational hypertension or preeclampsia, these outcomes stratified by presence of hyperuricemia at delivery since this denotes more severe disease, preterm birth or small for gestational age (SGA). Uric acid was measured in 1541 banked maternal plasma samples from a prior prospective cohort study that were collected at a mean gestational age of 9.0 (± 2.5) weeks. Polytomous regressions were performed and adjusted for parity and pre-pregnancy body mass index. First trimester uric acid in the highest quartile (>3.56 mg/dL) compared to lowest three quartiles was associated with an increased risk of developing preeclampsia (adjusted OR = 1.82; 95% CI, 1.03–3.21) but not gestational hypertension. In women with hypertensive disease complicated by hyperuricemia at delivery, high first trimester uric acid was associated with a 3.22-fold increased risk of hyperuricemic gestational hypertension and a 3.65-fold increased risk of hyperuricemic preeclampsia. High first trimester uric acid was not associated with gestational hypertension or preeclampsia without hyperuricemia at delivery, preterm birth, or SGA. In women who developed hypertensive disease, elevated uric acid at delivery was only partly explained by elevated uric acid in the first trimester (r2 = .23). First trimester elevated uric acid was associated with later preeclampsia and more strongly with preeclampsia and gestational hypertension with hyperuricemia.
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影响因子：
9.8
作者：
Laughon, S. Katherine;Catov, Janet;Roberts, James M.
通讯作者：
Roberts, James M.
影响因子：
8.3
作者：
Mellen, Philip B.;Bleyer, Anthony J.;Herrington, David M.
通讯作者：
Herrington, David M.
影响因子：
9.8
作者：
Powers, RW;Bodnar, LM;Roberts, JM
通讯作者：
Roberts, JM
影响因子：
2.4
作者：
deJong, CLD;Paarlberg, KM;Dekker, GA
通讯作者：
Dekker, GA
影响因子：
5.5
作者：
Bainbridge, Shannon A.;Roberts, James M.;Hubel, Carl A.
通讯作者：
Hubel, Carl A.