Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function.
Nicotine administration in adolescence reprograms the subsequent response to nicotine treatment and withdrawal in adulthood: sex-selective effects on cerebrocortical serotonergic function.
复制标题
DOI：
10.1016/j.brainresbull.2014.01.004
复制
发表时间：
2014-03
影响因子：
3.8
通讯作者：
Seidler FJ
中科院分区：
文献类型：
--
作者：
Slotkin TA;Card J;Seidler FJ
青少年时期的尼古丁暴露会导致对成瘾药物的后续行为反应发生持久变化。我们给予青春期大鼠尼古丁（出生后PN 30 -47天），模拟吸烟者的血浆水平，然后检查成年后再次给予尼古丁的后续影响（PN 90 -107），重点是大脑皮层5-羟色胺水平和利用率（周转率），作为涉及情绪状态的神经回路突触前活动的指标。我们的评价包括成人尼古丁治疗（PN 105）和戒断（PN 110，PN 120，PN 130）期间的反应，以及长期变化（PN 180）。在男性中，青春期尼古丁的既往暴露大大增加了成年后尼古丁引起的5-羟色胺周转率的增加，这种相互作用在戒断期间进一步加剧。这种效应足够大，导致血清素储备的显著消耗，这种效应在青少年或成年期单独给予尼古丁时没有观察到。在女性中，青少年尼古丁暴露减弱或延迟了从成人尼古丁治疗中撤出引起的血清素周转高峰，这与男性中观察到的相互作用完全不同。结合早期的工作显示持续失调的5-羟色胺受体的表达和受体偶联，目前的结果表明，青少年尼古丁暴露重新编程未来的反应5-HT系统尼古丁，变化可能会导致终身的脆弱性复发和再成瘾。
Nicotine exposure in adolescence produces lasting changes in subsequent behavioral responses to addictive agents. We gave nicotine to adolescent rats (postnatal days PN30-47), simulating plasma levels in smokers, and then examined the subsequent effects of nicotine given again in adulthood (PN90-107), focusing on cerebrocortical serotonin levels and utilization (turnover) as an index of presynaptic activity of circuits involved in emotional state. Our evaluations encompassed responses during the period of adult nicotine treatment (PN105) and withdrawal (PN110, PN120, PN130), as well as long-term changes (PN180). In males, prior exposure to nicotine in adolescence greatly augmented the increase in serotonin turnover evoked by nicotine given in adulthood, an interaction that was further exacerbated during withdrawal. The effect was sufficiently large that it led to significant depletion of serotonin stores, an effect that was not seen with nicotine given alone in either adolescence or adulthood. In females, adolescent nicotine exposure blunted or delayed the spike in serotonin turnover evoked by withdrawal from adult nicotine treatment, a totally different effect from the interaction seen in males. Combined with earlier work showing persistent dysregulation of serotonin receptor expression and receptor coupling, the present results indicate that adolescent nicotine exposure reprograms future responses of 5HT systems to nicotine, changes that may contribute to life-long vulnerability to relapse and re-addiction.
登录
查看更多内容
影响因子：
3.6
作者：
Faraday, MM;Elliott, BM;Grunberg, NE
通讯作者：
Grunberg, NE
影响因子：
2.5
作者：
McDonald, CG;Dailey, VK;Smith, RF
通讯作者：
Smith, RF
影响因子：
2.7
作者：
Marco, E. M.;Llorente, R.;Viveros, M. P.
通讯作者：
Viveros, M. P.
影响因子：
7.6
作者：
Abreu-Villaça, Y;Seidler, FJ;Slotkin, TA
通讯作者：
Slotkin, TA
影响因子：
3.4
作者：
Nakajima, Motohiro;al'Absi, Mustafa
通讯作者：
al'Absi, Mustafa