Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function.
Now open: Evolving insights to the roles of lysine acetylation in chromatin organization and function.
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DOI：
10.1016/j.molcel.2021.12.004
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发表时间：
2022-02-17
期刊：
影响因子：
16
通讯作者：
Dent SYR
中科院分区：
文献类型：
--
作者：
Chen YC;Koutelou E;Dent SYR
蛋白质乙酰化在整个系统发育过程中都是保守的，自近六十年前发现以来一直被认为是最重要的翻译后修饰之一。组蛋白乙酰化是开放染色质的活性标记特征，但特定赖氨酸残基和组蛋白变体的乙酰化发生在不同的生物环境中，并可能产生不同的结果。赖氨酸乙酰转移酶、脱乙酰酶和乙酰赖氨酸阅读器在发育障碍和病理学中的影响表明了乙酰化事件的重要性。最近的进展揭示了乙酰化调节因子在以染色质为中心的事件中的新作用，强调了这些功能网络的复杂性。在这篇综述中，我们讨论了染色质组织和 DNA 模板化过程中乙酰化的机制和动力学，包括基因转录、DNA 修复和复制。陈等人。深入研究染色质组织和 DNA 模板化过程中蛋白质乙酰化的机制和动力学，包括基因转录、DNA 修复和复制。新发现的乙酰化调节因子在以染色质为中心的事件中的作用对人类疾病具有影响。
Protein acetylation is conserved across phylogeny and has been recognized as one of the most prominent post-translational modifications since its discovery nearly sixty years ago. Histone acetylation is an active mark characteristic of open chromatin, but acetylation on specific lysine residues and histone variants occurs in different biological contexts and can confer varying outcomes. The significance of acetylation events is indicated by the implications of lysine acetyltransferases, deacetylases, and acetyl-lysine readers in developmental disorders and pathologies. Recent advances have uncovered new roles of acetylation regulators in chromatin-centric events, emphasizing the complexity of these functional networks. In this review, we discuss mechanisms and dynamics of acetylation in chromatin organization and DNA-templated processes, including gene transcription, DNA repair and replication. Chen et al. dive into the mechanisms and dynamics of protein acetylation in chromatin organization and DNA-templated processes, including gene transcription, DNA repair and replication. Newly discovered roles of acetylation regulators in chromatin-centric events have implications for human disease.
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