Flexible inorganic composite nanofibers with carboxyl modification for controllable drug delivery and enhanced optical monitoring functionality
Flexible inorganic composite nanofibers with carboxyl modification for controllable drug delivery and enhanced optical monitoring functionality
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具有羧基修饰的柔性无机复合纳米纤维可实现可控药物输送并增强光学监测功能
DOI：
10.1016/j.cej.2018.05.166
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发表时间：
2018-10
影响因子：
15.1
通讯作者：
Y.Z. Long
中科院分区：
文献类型：
--
作者：
S. Li;J. Zhang;D.D. Ju;X. Li;J.C. Zhang;X. Yan;H.D. Zhang;F. Song;Y.Z. Long
纳米纤维具有可控的药物释放和敏感的药物释放监测特性，可以调节药物释放速率，实时获得药物释放量与疗效之间的信息，在临床应用中具有重要意义。在此，我们介绍了一种不需要传统高温煅烧的再氧化法来制备柔性增强的无机纳米纤维。与传统的煅烧方法相比，该方法获得了更强的上转换发光。更有趣的是，用羧基修饰纳米纤维后，获得了更高的载药量和更慢的药物释放速率。红外光谱证实了DNR分子与羧基之间的离子相互作用是其主要机理。进一步的实验结果表明，可控的药物释放不仅可以通过这种羧基修饰，但也可以通过改变pH值。此外，由于这种再氧化法制备的纳米纤维具有更强的发光，他们表现出更灵敏的监测性能，特别是监测痕量药物释放，如1%，不能很好地监测由传统的煅烧方法制备的纳米纤维。
Nanofibers with controllable drug release and sensitive monitoring properties for drug delivery can regulate the drug release rate and obtain the real-time information between drug release amount and therapeutic effect, which are of great importance in clinical applications. Herein, we introduce a reoxidation method to prepare flexibility-enhanced inorganic nanofibers that does not need traditional high temperature calcination. Compared with traditional calcination methods, stronger upconversion luminescence is obtained via this method. More interestingly, higher drug loading capacity and slower drug releasing rate are obtained after nanofibers are modified with carboxyl. The main mechanism is ascribed to the ionic interaction between DNR molecules and carboxyl group verified by FTIR. Further experimental results show that controllable drug release can be achieved not only via this carboxyl modification, but also the change of pH. Moreover, thanks to nanofibers prepared by this reoxidation method possessing stronger luminescence, they exhibit more sensitive monitoring properties especially for monitoring trace drug release such as 1% which cannot be well monitored by nanofibers prepared by traditional calcination methods.
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