A Fibrous Localized Drug Delivery Platform with NIR-Triggered and Optically Monitored Drug Release.
A Fibrous Localized Drug Delivery Platform with NIR-Triggered and Optically Monitored Drug Release.
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具有近红外触发和光学监控药物释放的纤维局部药物输送平台
DOI：
10.1021/acs.langmuir.6b02227
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发表时间：
2016-09-06
期刊：
影响因子：
3.9
通讯作者：
Mao, Chuanbin
中科院分区：
文献类型：
--
作者：
Liu, Heng;Fu, Yike;Li, Yangyang;Ren, Zhaohui;Li, Xiang;Han, Gaorong;Mao, Chuanbin
具有智能功能的植入式局部给药系统(LDDS)已成为治疗癌症的强大化疗平台。开发具有合理控制药物释放和实时监测功能的LDDS有望实现个性化治疗方案，但面临着艰巨的挑战。为了克服这些挑战，合成了一系列具有特殊表面功能化的多孔Yb3+/Er3+共掺CaTiO3(CTO：Yb，Er)纳米纤维，用于阿霉素(DOX)的输送。在980 nm近红外(NIR)激发下，由于DOX分子与纳米纤维之间的荧光共振能量转移(FRET)效应，上转换光致发光纳米纤维的绿/红发射强度比(I550/I660)增大，从而可以光学监测DOX的释放量。更重要的是，808 nm的近红外辐射能够显著加速DOX的释放，证实了具有代表性的近红外触发药物释放特性。因此，这种CTO：Yb，Er纳米纤维在近红外辐射下表现出显著的体外抗癌效果。因此，这项研究启发了另一个有前景的光纤LDDS平台，它具有近红外触发和光学监控的DOX释放，用于个性化的肿瘤化疗。
Implantable localized drug delivery systems (LDDSs) with intelligent functionalities have emerged as a powerful chemotherapeutic platform in curing cancer. Developing LDDSs with rationally controlled drug release and real-time monitoring functionalities holds promise for personalized therapeutic protocols but suffers daunting challenges. To overcome such challenges, a series of porous Yb3+/Er3+ codoped CaTiO3 (CTO:Yb,Er) nanofibers, with specifically designed surface functionalization, were synthesized for doxorubicin (DOX) delivery. The content of DOX released could be optically monitored by increase in the intensity ratio of green to red emission (I550/I660) of upconversion photoluminescent nanofibers under 980 nm near-infrared (NIR) excitation owing to the fluorescence resonance energy transfer (FRET) effect between DOX molecules and the nanofibers. More importantly, the 808 nm NIR irradiation enabled markedly accelerated DOX release, confirming representative NIR-triggered drug release properties. In consequence, such CTO:Yb,Er nanofibers presented significantly enhanced in vitro anticancer efficacy under NIR irradiation. This study has thus inspired another promising fibrous LDDS platform with NIR-triggered and optics-monitored DOX releasing for personalized tumor chemotherapy.
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影响因子：
3
作者：
Tang, Hui;Wang, Fuping
通讯作者：
Wang, Fuping
影响因子：
8.6
作者：
Chen, Hongyu;Sulejmanovic, Dino;Moore, Thomas;Colvin, Daniel C.;Qi, Bin;Mefford, O. Thompson;Gore, John C.;Alexis, Frank;Hwu, Shiou-Jyh;Anker, Jeffrey N.
通讯作者：
Anker, Jeffrey N.
静电纺丝上转换复合纤维作为具有单独释放特性的双重药物输送系统
影响因子：
3.9
作者：
Hou, Zhiyao;Li, Xuejiao;Lin, Jun
通讯作者：
Lin, Jun
具有可调谐和可追踪药物释放动力学的近红外发光 CaTiO3:Nd3 纳米纤维
DOI：
10.1039/c5tb01158b
发表时间：
2015-10-07
期刊：
Journal of materials chemistry. B
影响因子：
--
作者：
Li X;Zhang Q;Ahmad Z;Huang J;Ren Z;Weng W;Han G;Mao C
通讯作者：
Mao C
影响因子：
14
作者：
Webber, Matthew J.;Matson, John B.;Tamboli, Vibha K.;Stupp, Samuel I.
通讯作者：
Stupp, Samuel I.