Damage to temporo-parietal cortex decreases incidental activation of thematic relations during spoken word comprehension.
Damage to temporo-parietal cortex decreases incidental activation of thematic relations during spoken word comprehension.
复制标题
DOI：
10.1016/j.neuropsychologia.2012.04.024
复制
发表时间：
2012-07
期刊：
影响因子：
2.6
通讯作者：
Graziano KM
中科院分区：
文献类型：
--
作者：
Mirman D;Graziano KM
分类语义关系和主题语义关系在行为学研究中得到了广泛的研究，并且有一个新兴的共识，即前颞叶在分类关系的表征和加工中起着特别重要的作用，但主题语义的神经基础尚不清楚。我们使用眼动追踪来检查失语症参与者在口语理解过程中分类和主题关系的偶然激活。三组参与者进行了测试：神经功能完好的对照组参与者（N=14），失语症的个人在左半球BA 39和周围的颞顶叶皮层区域的病变（N=7），和个人具有相同程度的失语症的严重程度和语义障碍和左前半球病变（主要是额下回和前颞叶），幸免BA 39（N=6）。后病变组表现出减少和延迟激活的主题关系，但不分类的关系。与此相反，前病变组表现出更持久的激活分类关系，并没有显着差异，从控制参与者的主题关系的激活。这些结果表明，分类和专题语义知识的功能和神经解剖学上的不同，颞顶叶皮层发挥了特别重要的作用，专题语义。
Both taxonomic and thematic semantic relations have been studied extensively in behavioral studies and there is an emerging consensus that the anterior temporal lobe plays a particularly important role in the representation and processing of taxonomic relations, but the neural basis of thematic semantics is less clear. We used eye tracking to examine incidental activation of taxonomic and thematic relations during spoken word comprehension in participants with aphasia. Three groups of participants were tested: neurologically intact control participants (N=14), individuals with aphasia resulting from lesions in left hemisphere BA 39 and surrounding temporo-parietal cortex regions (N=7), and individuals with the same degree of aphasia severity and semantic impairment and anterior left hemisphere lesions (primarily inferior frontal gyrus and anterior temporal lobe) that spared BA 39 (N=6). The posterior lesion group showed reduced and delayed activation of thematic relations, but not taxonomic relations. In contrast, the anterior lesion group exhibited longer-lasting activation of taxonomic relations and did not differ from control participants in terms of activation of thematic relations. These results suggest that taxonomic and thematic semantic knowledge are functionally and neuroanatomically distinct, with the temporo-parietal cortex playing a particularly important role in thematic semantics.
登录
查看更多内容
影响因子：
14.5
作者：
Kalenine, Solene;Buxbaum, Laurel J.;Coslett, Harry Branch
通讯作者：
Coslett, Harry Branch
影响因子：
2.5
作者：
Buxbaum, LJ;Giovannetti, T;Libon, D
通讯作者：
Libon, D
影响因子：
3.4
作者：
Crutch, Sebastian J.;Warrington, Elizabeth K.
通讯作者：
Warrington, Elizabeth K.
影响因子：
3.4
作者：
Altmann, GTM;Kamide, Y
通讯作者：
Kamide, Y
影响因子：
3.7
作者：
Binney, Richard J.;Embleton, Karl V.;Ralph, Matthew A. Lambon
通讯作者：
Ralph, Matthew A. Lambon