Triggered drug release from superhydrophobic meshes using high-intensity focused ultrasound.

Triggered drug release from superhydrophobic meshes using high-intensity focused ultrasound.
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DOI:
10.1002/adhm.201200381
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发表时间:
2013-09
影响因子:
10
通讯作者:
Grinstaff, Mark W.
Grinstaff, Mark W.
中科院分区:
工程技术1区
文献类型:
--
作者:
Yohe, Stefan T.;Kopechek, Jonathan A.;Porter, Tyrone M.;Colson, Yolonda L.;Grinstaff, Mark W.

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将高强度聚焦超声波应用于载药超疏水网格,通过置换截留的空气层来触发药物释放。使用直接可视化和 B 模式成像来表征超疏水网格内的空气层。在超声处理后的体外测定中,载药超疏水网具有细胞毒性。
Application of high-intensity focused ultrasound to drug-loaded superhydrophobic meshes affords triggered drug release by displacing an entrapped air layer. The air layer within the superhydrophobic meshes is characterized using direct visualization and B-mode imaging. Drug-loaded superhydrophobic meshes are cytotoxic in an in vitro assay after ultrasound treatment.
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