Imaging perivascular space structure and function using brain MRI.

Imaging perivascular space structure and function using brain MRI.
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DOI:
10.1016/j.neuroimage.2022.119329
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发表时间:
2022-08-15
期刊:
影响因子:
5.7
通讯作者:
Choupan, Jeiran
Choupan, Jeiran
中科院分区:
医学1区
文献类型:
--
作者:
Barisano, Giuseppe;Lynch, Kirsten M.;Sibilia, Francesca;Lan, Haoyu;Shih, Nien-Chu;Sepehrband, Farshid;Choupan, Jeiran

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在这篇文章中,我们提供了一个概述目前的神经影像学方法研究血管周围空间(PVS)在人类使用脑MRI。近年来,越来越多的研究强调了PVS在脑脊液/脑脊液循环和脑废物清除中的作用及其与神经系统疾病的关系。新的策略和技术已被引入,以提高PVS的量化,并研究其功能和形态特征的生理和病理条件。在简要介绍了PVS的解剖和生理学基础后,我们回顾了利用MRI定量分析人类PVS结构和功能的最新技术进展。我们描述了这些方法的应用,优点和局限性,提供指导和建议的收购协议和分析技术,可应用于研究PVS在体内。最后,我们回顾了人类神经影像学研究PVS的正常寿命和神经系统疾病的背景下。
In this article, we provide an overview of current neuroimaging methods for studying perivascular spaces (PVS) in humans using brain MRI. In recent years, an increasing number of studies highlighted the role of PVS in cerebrospinal/interstial fluid circulation and clearance of cerebral waste products and their association with neurological diseases. Novel strategies and techniques have been introduced to improve the quantification of PVS and to investigate their function and morphological features in physiological and pathological conditions. After a brief introduction on the anatomy and physiology of PVS, we examine the latest technological developments to quantitatively analyze the structure and function of PVS in humans with MRI. We describe the applications, advantages, and limitations of these methods, providing guidance and suggestions on the acquisition protocols and analysis techniques that can be applied to study PVS in vivo. Finally, we review the human neuroimaging studies on PVS across the normative lifespan and in the context of neurological disorders.
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