The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury.
The Role of Posttraumatic Hypothermia in Preventing Dendrite Degeneration and Spine Loss after Severe Traumatic Brain Injury.
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创伤后低温在预防严重创伤性脑损伤后树突变性和脊柱损失中的作用
DOI：
10.1038/srep37063
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发表时间：
2016-11-11
影响因子：
4.6
通讯作者：
Jiang JY
中科院分区：
文献类型：
--
作者：
Wang CF;Zhao CC;Jiang G;Gu X;Feng JF;Jiang JY
创伤后低温可防止创伤性脑损伤（TBI）后细胞死亡并促进功能结局。然而，关于低温对严重TBI后树突变性和脊柱丢失的影响知之甚少。在本研究中，我们使用thy 1-GFP转基因小鼠，以探讨低温对严重TBI后同侧皮质V/VI层树突和棘的影响。我们发现，低温（33 °C）显着防止CCI后1天和7天树突变性和棘丢失。Morris水迷宫实验显示，低温对CCI后小鼠的学习记忆功能有保护作用。与常温TBI组相比，低温可显著增加CCI后1 d和7 d同侧皮层和海马突触蛋白GluR 1和PSD-95的表达。低温还增加了皮质和海马BDNF水平。这些结果表明，创伤后低温是一种有效的方法，以防止树突变性和脊柱丢失，并保留严重TBI后的学习和记忆功能。增加皮层和海马BDNF水平可能是低温预防树突变性和脊髓缺失并保护学习和记忆功能的机制。
Posttraumatic hypothermia prevents cell death and promotes functional outcomes after traumatic brain injury (TBI). However, little is known regarding the effect of hypothermia on dendrite degeneration and spine loss after severe TBI. In the present study, we used thy1-GFP transgenic mice to investigate the effect of hypothermia on the dendrites and spines in layer V/VI of the ipsilateral cortex after severe TBI. We found that hypothermia (33 °C) dramatically prevented dendrite degeneration and spine loss 1 and 7 days after CCI. The Morris water maze test revealed that hypothermia preserved the learning and memory functions of mice after CCI. Hypothermia significantly increased the expression of the synaptic proteins GluR1 and PSD-95 at 1 and 7 days after CCI in the ipsilateral cortex and hippocampus compared with that of the normothermia TBI group. Hypothermia also increased cortical and hippocampal BDNF levels. These results suggest that posttraumatic hypothermia is an effective method to prevent dendrite degeneration and spine loss and preserve learning and memory function after severe TBI. Increasing cortical and hippocampal BDNF levels might be the mechanism through which hypothermia prevents dendrite degeneration and spine loss and preserves learning and memory function.
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影响因子：
12.7
作者：
JIANG, JY;LYETH, BG;POVLISHOCK, JT
通讯作者：
POVLISHOCK, JT
影响因子：
4.2
作者：
Brazinova A;Rehorcikova V;Taylor MS;Buckova V;Majdan M;Psota M;Peeters W;Feigin V;Theadom A;Holkovic L;Synnot A
通讯作者：
Synnot A
DOI：
10.1097/00004647-200207000-00009
发表时间：
2002-07-01
影响因子：
6.3
作者：
D'Cruz, BJ;Fertig, KC;Callaway, CW
通讯作者：
Callaway, CW
影响因子：
4.2
作者：
Posmantur, RM;Kampfl, A;Hayes, RL
通讯作者：
Hayes, RL
影响因子：
16.2
作者：
Kwon SE;Chapman ER
通讯作者：
Chapman ER