Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats.
Effects of chronic heavy alcohol consumption and endurance exercise on cancellous and cortical bone microarchitecture in adult male rats.
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慢性大量饮酒和耐力运动对成年雄性大鼠松质骨和皮质骨微结构的影响。
DOI：
10.1111/acer.12366
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发表时间：
2014-05
期刊：
影响因子：
--
通讯作者：
Iwaniec UT
中科院分区：
文献类型：
--
作者：
Johnson TL;Gaddini G;Branscum AJ;Olson DA;Caroline-Westerlind K;Turner RT;Iwaniec UT
骨骼健康受到许多生活方式因素的影响，包括饮食和运动。酒精是饮食中主要的非必需成分，对骨骼有剂量和环境依赖性影响。耐力运动与应力性骨折的风险增加有关。本研究的目的是确定长期的独立和联合的影响，慢性重度酒精消费和耐力运动（跑步机运行）对骨量和微结构的年轻成年雄性SD大鼠。将6月龄雄性大鼠随机分为4组（9-13只/组）：安静+对照饮食、安静+乙醇饮食、运动+对照饮食或运动+乙醇饮食。乙醇喂养的大鼠随意进食流质饮食（乙醇占热量摄入的35%）。对照组大鼠成对喂食相同的饮食，用麦芽糖-葡聚糖等热量替代乙醇。在电动跑步机上进行运动（15%等级，30分钟），每周5天，持续16周。使用密度测定法分析股骨和第12胸椎的骨矿物质含量（BMC）和密度（BMD），并使用微型计算机断层扫描分析皮质骨和松质骨结构。乙醇消耗导致股骨长度、BMC和BMD降低，股骨中段皮质体积、皮质厚度和极惯性矩降低。此外，乙醇喂养的大鼠椎骨中的骨小梁厚度较低。耐力运动对评价的任何终点均无独立影响。在股骨远端干骺端的几个松质骨终点检测到耐力运动和乙醇之间的显著相互作用。与消耗对照饮食的运动大鼠相比，消耗乙醇的运动大鼠具有较低的股骨远端干骺端骨体积/组织体积、骨小梁连接密度和骨小梁厚度。在该模型中获得的结果表明，慢性重度饮酒可能会降低骨骼的完整性，通过减少骨的大小，质量和密度，并通过消极改变松质骨微结构，并可能增加骨折的风险与耐力运动在承重骨骼网站。
Bone health is influenced by numerous lifestyle factors, including diet and exercise. Alcohol is a major non-essential constituent of diet and has dose and context-dependent effects on bone. Endurance exercise is associated with increased risk for stress fractures. The purpose of this study was to determine the long-term independent and combined effects of chronic heavy alcohol consumption and endurance exercise (treadmill running) on bone mass and microarchitecture in young adult male Sprague-Dawley rats. Six-month-old male rats were randomized into 4 groups (9–13 rats/group): sedentary+control diet, sedentary+ethanol diet, exercise+control diet, or exercise+ethanol diet. Ethanol-fed rats consumed a liquid diet (ethanol comprised 35% of caloric intake) ad libitum. Control rats were pair-fed the same diet with isocaloric substitution of ethanol with maltose-dextran. Exercise was conducted on a motorized treadmill (15% grade for 30 min) 5 days/week for 16 weeks. Femur and 12th thoracic vertebra were analyzed for bone mineral content (BMC) and density (BMD) using densitometry and cortical and cancellous bone architecture using microcomputed tomography. Ethanol consumption resulted in lower femur length, BMC, and BMD, and lower midshaft femur cortical volume, cortical thickness, and polar moment of inertia. In addition, trabecular thickness was lower in vertebra of ethanol-fed rats. Endurance exercise had no independent effect on any endpoints evaluated. A significant interaction between endurance exercise and ethanol was detected for several cancellous endpoints in the distal femur metaphysis. Ethanol-consuming rats that exercised had lower distal femur metaphysis bone volume/tissue volume, trabecular connectivity density, and trabecular thickness compared to exercising rats that consumed control diet. The results obtained in this model suggest that chronic heavy alcohol consumption may reduce skeletal integrity by reducing bone size, mass, and density, and by negatively altering cancellous bone microarchitecture and may increase fracture risk associated with endurance exercise at weight bearing skeletal sites.
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DOI：
10.1016/j.ecl.2012.04.006
发表时间：
2012-09-01
影响因子：
4.5
作者：
Armas, Laura A. G.;Recker, Robert R.
通讯作者：
Recker, Robert R.
影响因子：
3.3
作者：
BOURRIN, S;GENTY, C;ALEXANDRE, C
通讯作者：
ALEXANDRE, C
影响因子：
6.2
作者：
Fuchs, RK;Bauer, JJ;Snow, CM
通讯作者：
Snow, CM
影响因子：
1.2
作者：
Bray, Robert M.;Pemberton, Michael R.;Babeu, Lorraine A.
通讯作者：
Babeu, Lorraine A.
DOI：
10.1097/gme.0b013e31824ac071
发表时间：
2012-09-01
影响因子：
2.7
作者：
Marrone, Jill A.;Maddalozzo, Gianni F.;Iwaniec, Urszula T.
通讯作者：
Iwaniec, Urszula T.