Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
Transcriptional analysis reveals gender-specific changes in the aging of the human immune system.
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DOI：
10.1371/journal.pone.0066229
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发表时间：
2013
期刊：
影响因子：
3.7
通讯作者：
Hurme M
中科院分区：
文献类型：
--
作者：
Marttila S;Jylhävä J;Nevalainen T;Nykter M;Jylhä M;Hervonen A;Tserel L;Peterson P;Hurme M
年龄和性别对免疫系统的功能有很大的影响。一般来说，女性的免疫反应比男性强，但关于衰老对免疫反应性别差异的影响的信息很少。为了解决这个问题，我们进行了转录组学分析的外周血单核细胞来源于老年人（nonagenarians，n = 146）和年轻的控制（年龄19-30岁，n = 30）。 当与年轻对照组相比时，我们发现90岁女性和男性分别有339和248个基因差异表达（p<0.05，倍数变化>1.5或<-1.5），其中180个基因在两种性别中都发生了变化。对受影响的信号通路的分析显示出明显的性别偏见：女性中有48条通路发生了显著变化，而男性中只有29条通路发生了变化。男女共有24条途径。我们的研究结果表明，女性nonagenarians有较弱的T细胞防御和更突出的促炎反应相比，男性。在男性中，受影响的途径明显较少，其中两个已知受雌激素调节。这些数据表明，衰老对人体免疫系统的影响在男性和女性中有显着差异。
Aging and gender have a strong influence on the functional capacity of the immune system. In general, the immune response in females is stronger than that in males, but there is scant information about the effect of aging on the gender difference in the immune response. To address this question, we performed a transcriptomic analysis of peripheral blood mononuclear cells derived from elderly individuals (nonagenarians, n = 146) and young controls (aged 19–30 years, n = 30). When compared to young controls, we found 339 and 248 genes that were differentially expressed (p<0.05, fold change >1.5 or <−1.5) in nonagenarian females and males, respectively, 180 of these genes were changed in both genders. An analysis of the affected signaling pathways revealed a clear gender bias: there were 48 pathways that were significantly changed in females, while only 29 were changed in males. There were 24 pathways that were shared between both genders. Our results indicate that female nonagenarians have weaker T cell defenses and a more prominent pro-inflammatory response as compared to males. In males significantly fewer pathways were affected, two of which are known to be regulated by estrogen. These data show that the effects of aging on the human immune system are significantly different in males and females.
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影响因子：
4.5
作者：
Jylhava, Juulia;Eklund, Carita;Hurme, Mikko
通讯作者：
Hurme, Mikko
影响因子：
5.2
作者：
Mengel-From, Jonas;Thinggaard, Mikael;Christensen, Kaare
通讯作者：
Christensen, Kaare
DOI：
10.1093/gerona/gls068
发表时间：
2012-11-01
影响因子：
5.1
作者：
Horstman, Astrid M.;Dillon, E. Lichar;Sheffield-Moore, Melinda
通讯作者：
Sheffield-Moore, Melinda
影响因子：
4.4
作者：
Kallio MA;Tuimala JT;Hupponen T;Klemelä P;Gentile M;Scheinin I;Koski M;Käki J;Korpelainen EI
通讯作者：
Korpelainen EI
影响因子：
5.3
作者：
Franceschi, Claudio;Capri, Miriam;Salvioli, Stefano
通讯作者：
Salvioli, Stefano