Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.
Coordinated hippocampal-thalamic-cortical communication crucial for engram dynamics underneath systems consolidation.
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DOI：
10.1038/s41467-022-28339-z
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发表时间：
2022-02-11
影响因子：
16.6
通讯作者：
Clopath C
中科院分区：
文献类型：
--
作者：
Tomé DF;Sadeh S;Clopath C
系统巩固是指记忆表征或印记在大脑区域的时间依赖性重组。尽管最近在解开这一过程方面取得了进展，但印迹动力学背后的确切机制和相关途径的作用在很大程度上仍然未知。在这里，我们提出了一个生物学上合理的计算模型来解决这一知识差距。通过协调突触可塑性的时间尺度，并结合海马体-丘脑-皮层回路，我们的模型能够耦合这些区域的印痕再激活，从而重现皮层和海马体印痕细胞及其相互依赖性的关键动力学。海马体-丘脑-皮质活动的解耦破坏了系统的巩固。至关重要的是，我们的模型对海马和丘脑印记细胞、抑制性印记、丘脑抑制性输入以及丘脑皮质突触偶联对海马病变诱导的逆行性遗忘的影响产生了可测试的预测。总的来说，我们的研究结果表明，系统巩固来自于分布在大脑区域的印痕细胞的耦合再激活，这是由多突触皮层下-皮层回路中协调的突触可塑性时间尺度实现的。系统巩固是指大脑各区域记忆印痕的重组。作者提出了一个生物学上合理的计算模型，表明海马体-丘脑-皮层活动对系统巩固至关重要，为实验神经科学做出了可测试的预测。
Systems consolidation refers to the time-dependent reorganization of memory representations or engrams across brain regions. Despite recent advancements in unravelling this process, the exact mechanisms behind engram dynamics and the role of associated pathways remain largely unknown. Here we propose a biologically-plausible computational model to address this knowledge gap. By coordinating synaptic plasticity timescales and incorporating a hippocampus-thalamus-cortex circuit, our model is able to couple engram reactivations across these regions and thereby reproduce key dynamics of cortical and hippocampal engram cells along with their interdependencies. Decoupling hippocampal-thalamic-cortical activity disrupts systems consolidation. Critically, our model yields testable predictions regarding hippocampal and thalamic engram cells, inhibitory engrams, thalamic inhibitory input, and the effect of thalamocortical synaptic coupling on retrograde amnesia induced by hippocampal lesions. Overall, our results suggest that systems consolidation emerges from coupled reactivations of engram cells in distributed brain regions enabled by coordinated synaptic plasticity timescales in multisynaptic subcortical-cortical circuits. Systems consolidation refers to the reorganization of memory engrams across brain regions. The authors present a biologically-plausible computational model that shows that hippocampal-thalamic-cortical activity is crucial for systems consolidation, making testable predictions for experimental neuroscience.
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影响因子：
4.3
作者：
Clopath, Claudia;Ziegler, Lorric;Vasilaki, Eleni;Buesing, Lars;Gerstner, Wulfram
通讯作者：
Gerstner, Wulfram
影响因子：
16.6
作者：
Espinoza C;Guzman SJ;Zhang X;Jonas P
通讯作者：
Jonas P
影响因子：
3.5
作者：
Kawashima T;Okuno H;Bito H
通讯作者：
Bito H
影响因子：
16.2
作者：
Kaefer, Karola;Nardin, Michele;Csicsvari, Jozsef
通讯作者：
Csicsvari, Jozsef
DOI：
10.1177/1073858414529829
发表时间：
2014-10
期刊：
The Neuroscientist : a review journal bringing neurobiology, neurology and psychiatry
影响因子：
--
作者：
Chistiakova M;Bannon NM;Bazhenov M;Volgushev M
通讯作者：
Volgushev M