Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity.
Baseline effects of transcranial direct current stimulation on glutamatergic neurotransmission and large-scale network connectivity.
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DOI：
10.1016/j.brainres.2014.09.066
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发表时间：
2015-01-12
期刊：
影响因子：
2.9
通讯作者：
Clark, Vincent P.
中科院分区：
文献类型：
--
作者：
Hunter, Michael A.;Coffman, Brian A.;Gasparovic, Charles;Calhoun, Vince D.;Trumbo, Michael C.;Clark, Vincent P.
关键词：
经颅直流电刺激(TDC)调节谷氨酸能神经传递，可作为一种新的治疗干预方法用于多种人群。然而，tDCs从微观到宏观调控大脑神经结构的确切机制尚未阐明。采用受试者内设计，在右侧顶叶皮质正极TDC注射前和注射后即刻分别进行静息状态功能磁共振成像(RS-fMRI)和质子磁共振波谱(1H-MRS)检查。使用组独立分量分析(ICA)将fMRI扫描分解成75个脑网络，从中识别出12个与感兴趣解剖区域具有显著体素功能连接的静息状态网络。用1H-MRS估计双侧顶内沟谷氨酸和谷氨酰胺(GLX)的结合浓度。配对样本t检验显示，正极电极下的GLX显著增加，但对侧大脑半球的相应区域没有明显增加。顶上、下顶叶、左额-顶叶、凸起和小脑内部网络的连通性增加，而前扣带回和基底节的连通性降低(p<；0.05，FDR校正)。GLX浓度的个体差异预测了这些网络中的大多数网络连接。观察到的谷氨酸能神经传递和网络连通性之间的关系可能被用来指导未来的tdcs方案，该方案旨在靶向和改变健康个体以及精神和神经疾病患者的神经再生机制。
Transcranial direct current stimulation (tDCS) modulates glutamatergic neurotransmission and can be utilized as a novel treatment intervention for a multitude of populations. However, the exact mechanism by which tDCS modulates the brain’s neural architecture, from the micro to macro scales, have yet to be illuminated. Using a within-subjects design, resting-state functional magnetic resonance imaging (rs-fMRI) and proton magnetic resonance spectroscopy (1H-MRS) were performed immediately before and after the administration of anodal tDCS over right parietal cortex. Group independent component analysis (ICA) was used to decompose fMRI scans into 75 brain networks, from which 12 resting-state networks were identified that had significant voxel-wise functional connectivity to anatomical regions of interest. 1H-MRS was used to obtain estimates of combined glutamate and glutamine (Glx) concentrations from bilateral intraparietal sulcus. Paired sample t-tests showed significantly increased Glx under the anodal electrode, but not in homologous regions of the contralateral hemisphere. Increases of within-network connectivity were observed within the superior parietal, inferior parietal, left frontal-parietal, salience and cerebellar intrinsic networks, and decreases in connectivity were observed in the anterior cingulate and the basal ganglia (p < 0.05, FDR-corrected). Individual differences in Glx concentrations predicted network connectivity in most of these networks. The observed relationships between glutamatergic neurotransmission and network connectivity may be used to guide future tDCS protocols that aim to target and alter neuroplastic mechanisms in healthy individuals as well as those with psychiatric and neurologic disorders.
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影响因子：
5.7
作者：
Amadi U;Ilie A;Johansen-Berg H;Stagg CJ
通讯作者：
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DOI：
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DOI：
10.1073/pnas.1000496107
发表时间：
2010-05-04
影响因子：
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作者：
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