Introduction to laser thermal therapy for brain disorders.
Introduction to laser thermal therapy for brain disorders.
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DOI：
10.1080/02656736.2020.1789764
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发表时间：
2020-07
期刊：
影响因子：
--
通讯作者：
Mohammadi AM
中科院分区：
文献类型：
--
作者：
Yu JS;Mohammadi AM
热疗因其治疗特性而长期被医学界所认可。虽然热疗已广泛用于颅外多年，但其在大脑中的使用受到技术和安全问题的阻碍。微波热疗的III期临床试验延长了胶质母细胞瘤（一种致命的原发性脑肿瘤）患者的生存期[1]。然而，微波组织间导管植入的技术挑战，温度测量的局限性，质量和安全问题，以及缺乏对医生和外科医生进行该技术培训的计划导致其被放弃。不幸的是，脑热疗的早期成功被搁置一边。主流医学转向了新的化疗、靶向药物和免疫疗法。过去几年，热疗在大脑中的应用又重新兴起。激光、超声和MRI技术的进步改善了热疗的实施和质量。目标的立体定向标测结合实时测温已经能够安全地进行热疗。这些进展重新引起了人们对热疗治疗脑肿瘤的兴趣。此外，适应症已扩展至包括治疗放射性坏死（通常用于治疗脑转移瘤的放射外科手术并发症）和功能性疾病（包括癫痫）。由于其微创技术，脑热疗，特别是激光消融，提供了一个有吸引力的替代传统开颅手术。随着恢复时间和住院时间的缩短，患者可以更快地进行放射治疗或全身治疗。脑热疗的临床和经济价值正日益被认识到。
Hyperthermia has long been recognized in medicine for its therapeutic properties. While hyperthermia has become widely used extracranially for many years, its use in the brain has been hampered by technical and safety concerns. A phase-III clinical trial with microwave hyperthermia led to prolongation of survival in patients with glioblastoma, a lethal primary brain tumor [1]. Yet, technical challenges in microwave interstitial catheter implantation, limitations in thermometry, quality and safety concerns, and lack of programs to train physicians and surgeons in this technique led to its abandonment. Unfortunately, the early success with brain hyperthermia was cast aside. Mainstream medicine moved on to new chemotherapies, targeted agents and immunotherapy.The last few years have ushered a resurgence of hyperthermia applications in the brain. Advances in laser, ultrasound and MRI technologies have improved the delivery and quality of hyperthermia. Stereotactic mapping of targets coupled with real-time thermometry has enabled safe delivery of hyperthermia. These advances have renewed interest in hyperthermia in the management of brain tumors. Additionally, indications have expanded to include treatment of radiation necrosis, a complication of radiosurgery commonly used to treat brain metastases, and functional disorders including epilepsy. Due to its minimally invasive technique, brain hyperthermia, particularly laser ablation, offers an appealing alternative to traditional craniotomy. With reduced recovery time and length of hospitalization, patients may go on to radiation therapy or systemic treatment more quickly. The clinical and economic value of brain hyperthermia is increasingly being realized.
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影响因子：
11.2
作者：
Man J;Shoemake JD;Ma T;Rizzo AE;Godley AR;Wu Q;Mohammadi AM;Bao S;Rich JN;Yu JS
通讯作者：
Yu JS
影响因子：
17.1
作者：
Atkinson RL;Zhang M;Diagaradjane P;Peddibhotla S;Contreras A;Hilsenbeck SG;Woodward WA;Krishnan S;Chang JC;Rosen JM
通讯作者：
Rosen JM
热疗法对血脑屏障和血肿瘤屏障的影响。
DOI：
10.1080/02656736.2020.1783461
发表时间：
2020-07
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Patel B;Yang PH;Kim AH
通讯作者：
Kim AH
影响因子：
3.1
作者：
Srinivasan, Ethan S.;Sankey, Eric W.;Fecci, Peter E.
通讯作者：
Fecci, Peter E.
DOI：
10.1080/02656736.2020.1772512
发表时间：
2020-07
期刊：
International journal of hyperthermia : the official journal of European Society for Hyperthermic Oncology, North American Hyperthermia Group
影响因子：
--
作者：
Skandalakis GP;Rivera DR;Rizea CD;Bouras A;Jesu Raj JG;Bozec D;Hadjipanayis CG
通讯作者：
Hadjipanayis CG