Selective atrophy of left hemisphere and frontal lobe of the brain in old men.

Selective atrophy of left hemisphere and frontal lobe of the brain in old men.
复制标题

老年人大脑左半球和额叶选择性萎缩。

DOI:
10.1093/gerona/60.2.165
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发表时间:
2005
期刊:
The journals of gerontology. Series A, Biological sciences and medical sciences
影响因子:
--
通讯作者:
Yue,GuangH
Yue,GuangH
中科院分区:
--
文献类型:
--
作者:
Shan,ZuY;Liu,JingZ;Sahgal,Vinod;Wang,Bin;Yue,GuangH

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在这项研究中,通过自动化方法对年轻人和老年人的整个大脑、半球和额叶的体积进行了量化。评估了年龄、性别和侧面对大脑结构绝对和相对体积的影响。与年轻组相比,老年参与者的整个大脑和半球体积减少了 15%,额叶体积减少了 22%。老年人左半球的相对体积比右半球减少得更多。老年男性的左半球和左额叶体积损失明显大于老年女性,这表明左半球相对体积减少幅度较大,很大程度上是由老年男性左额叶体积的选择性萎缩造成的。这些结果可能反映了左脑与年龄和性别相关的功能退化。
In this study, volumes of the whole brain, hemispheres, and frontal lobes of young and elderly adults were quantified by an automated method. Effects of age, sex, and side on absolute and relative volumes of the brain structures were evaluated. Compared with the young group, elderly participants showed a 15% volume loss in the whole brain and hemispheres, and a 22% volume loss in the frontal lobes. The relative volume of the left hemisphere in the elderly group decreased more than that of the right hemisphere. Elderly men showed significantly greater left hemisphere and left frontal lobe volume losses than did elderly women, indicating that the larger left hemisphere relative volume reduction is largely contributed to by selective atrophy of the left frontal lobe volume in elderly men. These results may reflect age- and sex-related functional deterioration in the left brain.
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DOI: --
发表时间: 2000
期刊:
影响因子: --
作者:
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