Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron.
Differential expression of cell-cell and cell-substratum adhesion proteins along the kidney nephron.
复制标题
肾单位细胞间和细胞基质粘附蛋白的差异表达。
DOI：
10.1152/ajpcell.1995.269.6.c1433
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发表时间：
1995
期刊：
影响因子：
--
通讯作者：
Nelson,WJ
中科院分区：
文献类型：
--
作者：
Piepenhagen,PA;Nelson,WJ
Structural and functional differences among epithelial cells of kidney nephrons may be regulated by variations in cell-to-cell (cell-cell) and cell-to-substratum (cell-substratum) junctions. Using immunofluorescence microscopy, we demonstrate that the cadherin-associated proteins alpha- and beta-catenin are localized to basolateral membranes of cells in all nephron segments, whereas plakoglobin, a protein associated with both classical and desmosomal cadherins, is localized to noninterdigitated lateral membranes in the distal half of the nephron where it colocalizes with desmoplakin and cytokeratin K8. Plakoglobin is also present in capillary endothelial cells where staining for the other catenins and desmosomal proteins is not observed. Immunofluorescence for laminin A and alpha 6-integrin, proteins that mediate cell-substratum contacts, reveal no correlations with the other staining patterns observed. These data indicate that plakoglobin and beta-catenin subserve distinct functions in cell-cell adhesion and suggest that E-cadherin-mediated contacts generate a basal level of cell-cell adhesion, whereas desmosomal junctions provide additional strength to cell-cell contacts in the distal nephron.
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影响因子：
64.5
作者：
PEIFER, M;WIESCHAUS, E
通讯作者：
WIESCHAUS, E
影响因子：
64.5
作者：
KLEIN, G;LANGEGGER, M;EKBLOM, P
通讯作者：
EKBLOM, P
DOI：
10.1083/jcb.113.2.381
发表时间：
1991-04
期刊：
The Journal of cell biology
影响因子：
--
作者：
Collins JE;Legan PK;Kenny TP;MacGarvie J;Holton JL;Garrod DR
通讯作者：
Garrod DR
影响因子：
56.9
作者：
MCCREA, PD;TURCK, CW;GUMBINER, B
通讯作者：
GUMBINER, B
DOI：
10.1073/pnas.89.15.7075
发表时间：
1992-08-01
影响因子：
11.1
作者：
KURIHARA, H;ANDERSON, JM;FARQUHAR, MG
通讯作者：
FARQUHAR, MG