Associations between exposure to cadmium, lead, mercury and mixtures and women's infertility and long-term amenorrhea.
Associations between exposure to cadmium, lead, mercury and mixtures and women's infertility and long-term amenorrhea.
复制标题
DOI：
10.1186/s13690-023-01172-6
复制
发表时间：
2023-08-25
期刊：
影响因子：
--
通讯作者：
Xiao S
中科院分区：
文献类型：
--
作者：
McClam M;Liu J;Fan Y;Zhan T;Zhang Q;Porter DE;Scott GI;Xiao S
镉（Cd）、铅（Pb）和汞（Hg）已被证明具有内分泌干扰特性。然而，它们对妇女生殖健康的影响仍然难以捉摸。在这里，我们使用美国国家健康和营养调查（NHANES）2013-2018年横断面调查，调查了20-49岁女性中Pb，Cd，Hg及其混合物的血液浓度与不孕症和长期闭经之间的关系。共有1，990名妇女被纳入不孕症分析，1，919名妇女长期闭经。采用对数转换和四分位数分析法对血液中重金属浓度进行分析。使用卡方检验（分类变量）和t检验（连续变量）评价结局组之间协变量的统计学差异。多元逻辑回归模型被用来检查协会。铅和重金属混合物的血液浓度显着高于以往不孕妇女比孕妇，但镉和汞的浓度是可比的。经充分调整后，多元Logistic回归分析显示，血铅浓度和妇女的历史不孕症，镉和妇女的长期闭经之间的负相关，并没有关联汞和重金属混合物和妇女的不孕症或长期闭经之间的显着和剂量依赖性的正相关。我们的研究表明，暴露于重金属表现出不同的协会与历史的不孕症和闭经，铅可能会产生不利影响妇女的生殖和增加的风险，不孕症和长期闭经。
Cadmium (Cd), lead (Pb), and mercury (Hg) have been shown to exhibit endocrine disrupting properties. Their effects on women’s reproductive health, however, remain elusive. Here, we investigated associations between blood concentrations of Pb, Cd, Hg, and their mixture and infertility and long-term amenorrhea in women aged 20–49 years using the US National Health and Nutrition Examination Survey (NHANES) 2013–2018 cross-sectional survey. A total of 1,990 women were included for the analysis of infertility and 1,919 women for long-term amenorrhea. The methods of log-transformation and use of quartiles were used to analyze blood heavy metal concentrations. Statistical differences in the covariates between the outcome groups were evaluated using a chi-squared test for categorical variables and a t-test for continuous variables. Multiple logistic regression models were used to examine the associations. The blood concentrations of Pb and heavy metal mixtures were significantly higher in ever-infertile women than pregnant women, but the concentrations of Cd and Hg were comparable. After full adjustment, multiple logistic regression analyses revealed a significant and dose-dependent positive association between blood Pb concentrations and women’s historical infertility, a negative association between Cd and women’s long-term amenorrhea, and no associations between Hg and heavy metal mixture and women’s infertility or long-term amenorrhea. Our study suggests that exposure to heavy metals exhibit differential associations with history of infertility and amenorrhea, and Pb may adversely impact women’s reproduction and heighten the risks of infertility and long-term amenorrhea.
登录
查看更多内容
DOI：
10.1078/1438-4639-00155
发表时间：
2002-05-01
影响因子：
6
作者：
Becker, K;Kaus, S;Seifert, B
通讯作者：
Seifert, B
影响因子：
3.1
作者：
Achrekar, Swati K.;Modi, Deepak N.;Mahale, Smita D.
通讯作者：
Mahale, Smita D.
镉对健康风险评估的毒理动力学建模。
影响因子：
10.4
作者：
Amzal B;Julin B;Vahter M;Wolk A;Johanson G;Akesson A
通讯作者：
Akesson A
影响因子：
7.2
作者：
通讯作者：
--
影响因子：
3.3
作者：
Bloom, Michael S.;Louis, Germaine M. Buck;Jain, Jinesh
通讯作者：
Jain, Jinesh