The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment.
The regulatory role of endoplasmic reticulum chaperone proteins in neurodevelopment.
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DOI：
10.3389/fnins.2022.1032607
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发表时间：
2022
影响因子：
4.3
通讯作者：
Zhu, Jia
中科院分区：
文献类型：
--
作者：
Sun, Hongji;Wu, Mengxue;Wang, Minxin;Zhang, Xiaomin;Zhu, Jia
关键词：
内质网是细胞内最大的管状网状细胞器。ER作为蛋白质合成、维持Ca ~（2+）稳态和脂质代谢的主要场所，在真核细胞中发挥着多种重要作用，ER分子伴侣参与了这些过程。近年来，研究发现ER伴侣蛋白的异常表达可导致多种神经发育障碍，包括神经元迁移、神经元形态发生和突触功能的异常。神经元的发育是一个复杂而精确调控的过程。目前，神经发育在内质网水平的调节机制仍在研究中。因此，本文综述了ER分子伴侣在神经发育中的作用以及这些分子伴侣缺乏引起的发育障碍的最新进展。
The endoplasmic reticulum (ER) is the largest tubular reticular organelle spanning the cell. As the main site of protein synthesis, Ca2+ homeostasis maintenance and lipid metabolism, the ER plays a variety of essential roles in eukaryotic cells, with ER molecular chaperones participate in all these processes. In recent years, it has been reported that the abnormal expression of ER chaperones often leads to a variety of neurodevelopmental disorders (NDDs), including abnormal neuronal migration, neuronal morphogenesis, and synaptic function. Neuronal development is a complex and precisely regulated process. Currently, the mechanism by which neural development is regulated at the ER level remains under investigation. Therefore, in this work, we reviewed the recent advances in the roles of ER chaperones in neural development and developmental disorders caused by the deficiency of these molecular chaperones.
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影响因子：
16.6
作者：
Bocchi R;Egervari K;Carol-Perdiguer L;Viale B;Quairiaux C;De Roo M;Boitard M;Oskouie S;Salmon P;Kiss JZ
通讯作者：
Kiss JZ
影响因子：
3.7
作者：
Jin H;Mimura N;Kashio M;Koseki H;Aoe T
通讯作者：
Aoe T
影响因子：
--
作者：
Bostan, Andreea C;Dum, Richard P;Strick, Peter L
通讯作者：
Strick, Peter L
影响因子：
3.5
作者：
Bertling, Enni;Hotulainen, Pirta
通讯作者：
Hotulainen, Pirta
DOI：
10.3109/17482968.2010.502940
发表时间：
2011-01
期刊：
Amyotrophic lateral sclerosis : official publication of the World Federation of Neurology Research Group on Motor Neuron Diseases
影响因子：
--
作者：
Beghi E;Chiò A;Couratier P;Esteban J;Hardiman O;Logroscino G;Millul A;Mitchell D;Preux PM;Pupillo E;Stevic Z;Swingler R;Traynor BJ;Van den Berg LH;Veldink JH;Zoccolella S;Eurals Consortium
通讯作者：
Eurals Consortium